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Prediction model for an early revision for dislocation after primary total hip arthroplasty

Dislocation is one of the most common complications after primary total hip arthroplasty (THA). Several patient-related risk factors for dislocation have been reported in the previous literature, but only few prediction models for dislocation have been made. Our aim was to build a prediction model f...

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Autores principales: Pakarinen, Oskari, Karsikas, Mari, Reito, Aleksi, Lainiala, Olli, Neuvonen, Perttu, Eskelinen, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462822/
https://www.ncbi.nlm.nih.gov/pubmed/36084121
http://dx.doi.org/10.1371/journal.pone.0274384
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author Pakarinen, Oskari
Karsikas, Mari
Reito, Aleksi
Lainiala, Olli
Neuvonen, Perttu
Eskelinen, Antti
author_facet Pakarinen, Oskari
Karsikas, Mari
Reito, Aleksi
Lainiala, Olli
Neuvonen, Perttu
Eskelinen, Antti
author_sort Pakarinen, Oskari
collection PubMed
description Dislocation is one of the most common complications after primary total hip arthroplasty (THA). Several patient-related risk factors for dislocation have been reported in the previous literature, but only few prediction models for dislocation have been made. Our aim was to build a prediction model for an early (within the first 2 years) revision for dislocation after primary THA using two different statistical methods. The study data constituted of 37 pre- or perioperative variables and postoperative follow-up data of 16 454 primary THAs performed at our institution in 2008–2021. Model I was a traditional logistic regression model and Model II was based on the elastic net method that utilizes machine learning. The models’ overall performance was measured using the pseudo R(2) values. The discrimination of the models was measured using C-index in Model I and Area Under the Curve (AUC) in Model II. Calibration curves were made for both models. At 2 years postoperatively, 95 hips (0.6% prevalence) had been revised for dislocation. The pseudo R(2) values were 0.04 in Model I and 0.02 in Model II indicating low predictive capability in both models. The C-index in Model I was 0.67 and the AUC in Model II was 0.73 indicating modest discrimination. The prediction of an early revision for dislocation after primary THA is difficult even in a large cohort of patients with detailed data available because of the reasonably low prevalence and multifactorial nature of dislocation. Therefore, the risk of dislocation should be kept in mind in every primary THA, whether the patient has predisposing factors for dislocation or not. Further, when conducting a prediction model, sophisticated methods that utilize machine learning may not necessarily offer significant advantage over traditional statistical methods in clinical setup.
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spelling pubmed-94628222022-09-10 Prediction model for an early revision for dislocation after primary total hip arthroplasty Pakarinen, Oskari Karsikas, Mari Reito, Aleksi Lainiala, Olli Neuvonen, Perttu Eskelinen, Antti PLoS One Research Article Dislocation is one of the most common complications after primary total hip arthroplasty (THA). Several patient-related risk factors for dislocation have been reported in the previous literature, but only few prediction models for dislocation have been made. Our aim was to build a prediction model for an early (within the first 2 years) revision for dislocation after primary THA using two different statistical methods. The study data constituted of 37 pre- or perioperative variables and postoperative follow-up data of 16 454 primary THAs performed at our institution in 2008–2021. Model I was a traditional logistic regression model and Model II was based on the elastic net method that utilizes machine learning. The models’ overall performance was measured using the pseudo R(2) values. The discrimination of the models was measured using C-index in Model I and Area Under the Curve (AUC) in Model II. Calibration curves were made for both models. At 2 years postoperatively, 95 hips (0.6% prevalence) had been revised for dislocation. The pseudo R(2) values were 0.04 in Model I and 0.02 in Model II indicating low predictive capability in both models. The C-index in Model I was 0.67 and the AUC in Model II was 0.73 indicating modest discrimination. The prediction of an early revision for dislocation after primary THA is difficult even in a large cohort of patients with detailed data available because of the reasonably low prevalence and multifactorial nature of dislocation. Therefore, the risk of dislocation should be kept in mind in every primary THA, whether the patient has predisposing factors for dislocation or not. Further, when conducting a prediction model, sophisticated methods that utilize machine learning may not necessarily offer significant advantage over traditional statistical methods in clinical setup. Public Library of Science 2022-09-09 /pmc/articles/PMC9462822/ /pubmed/36084121 http://dx.doi.org/10.1371/journal.pone.0274384 Text en © 2022 Pakarinen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pakarinen, Oskari
Karsikas, Mari
Reito, Aleksi
Lainiala, Olli
Neuvonen, Perttu
Eskelinen, Antti
Prediction model for an early revision for dislocation after primary total hip arthroplasty
title Prediction model for an early revision for dislocation after primary total hip arthroplasty
title_full Prediction model for an early revision for dislocation after primary total hip arthroplasty
title_fullStr Prediction model for an early revision for dislocation after primary total hip arthroplasty
title_full_unstemmed Prediction model for an early revision for dislocation after primary total hip arthroplasty
title_short Prediction model for an early revision for dislocation after primary total hip arthroplasty
title_sort prediction model for an early revision for dislocation after primary total hip arthroplasty
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462822/
https://www.ncbi.nlm.nih.gov/pubmed/36084121
http://dx.doi.org/10.1371/journal.pone.0274384
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