Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids (Adv. Sci. 24/2022)

Mesenchymal Stromal Cells In article number 2200431, Wenjun Yan, Ling Tao, and co‐workers report a novel strategy for improving the curative effect of mesenchymal stromal cell (MSC)‐based therapy for myocardial infarction that is achieved by bile acid‐ arnesoid X receptor (FXR) axis activation. FXR...

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Detalles Bibliográficos
Autores principales: Xia, Yunlong, Xu, Xinyue, Guo, Yongzhen, Lin, Chen, Xu, Xiaoming, Zhang, Fuyang, Fan, Miaomiao, Qi, Tingting, Li, Congye, Hu, Guangyu, Peng, Lu, Wang, Shan, Zhang, Ling, Hai, Chunxu, Liu, Rui, Yan, Wenjun, Tao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462841/
http://dx.doi.org/10.1002/advs.202270152
Descripción
Sumario:Mesenchymal Stromal Cells In article number 2200431, Wenjun Yan, Ling Tao, and co‐workers report a novel strategy for improving the curative effect of mesenchymal stromal cell (MSC)‐based therapy for myocardial infarction that is achieved by bile acid‐ arnesoid X receptor (FXR) axis activation. FXR overexpression in MSC facilitates the response of MSC to endogenous bile acid signals, thus enhancing the survival and paracrine angiogenesis of MSC. [Image: see text]

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