High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using th...

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Detalles Bibliográficos
Autores principales: Gonçalves Antunes, Marina, Sanial, Matthieu, Contremoulins, Vincent, Carvalho, Sandra, Plessis, Anne, Becam, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462849/
https://www.ncbi.nlm.nih.gov/pubmed/36083801
http://dx.doi.org/10.7554/eLife.79843

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