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THYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISMS AND SUSCEPTIBILITY TO ESOPHAGEAL CANCER: A CASE-CONTROL STUDY

BACKGROUND: The enzyme methylenetetrahydrofolate reductase is engaged in DNA synthesis through folate metabolism. Inhibiting the activity of this enzyme increases the susceptibility to mutations, and damage and aberrant DNA methylation, which alters the gene expression of tumor suppressors and proto...

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Detalles Bibliográficos
Autores principales:	Zaidan, Evelise Pelegrinelli, Tomitão, Michele Tatiana Pereira, Pereira, Marina Alessandra, Kubrusly, Marcia Saldanha, Vaz Safatle-Ribeiro, Adriana, Takeda, Flavio Roberto, Cecconello, Ivan, Ribeiro, Ulysses
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Colégio Brasileiro de Cirurgia Digestiva 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462861/ https://www.ncbi.nlm.nih.gov/pubmed/36102491 http://dx.doi.org/10.1590/0102-672020220002e1684

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