Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats

PURPOSE: Endoplasmic reticulum stress (ERS) plays an important role in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Cyclic GMP-AMP synthase (cGAS) is a cytosol dsDNA sensor, coupling with downstream stimulator of interferon genes (STING) located in the ER, which involves innate immune...

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Detalles Bibliográficos
Autores principales: Huang, Renhui, Shi, Qi, Zhang, Shutian, Lin, Hong, Han, Chengzhi, Qian, Xinyi, Huang, Yijun, Ren, Xiaorong, Sun, Jiayuan, Feng, Nana, Xia, Chunmei, Shi, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462969/
https://www.ncbi.nlm.nih.gov/pubmed/36091334
http://dx.doi.org/10.2147/JIR.S365970

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