Cargando…

Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer

Patients with a previous cancer history (PCA) are routinely excluded from most clinical trials, which may limit the accuracy and universality of clinical trials. We aimed to explore the association between PCA and survival of patients with different molecular subtypes of breast cancer. Patients diag...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Weixun, Chen, Yaokun, Ji, Zeqi, Chen, Lingzhi, Wu, Jinyao, Chen, Yexi, Li, Zhiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462974/
https://www.ncbi.nlm.nih.gov/pubmed/36093405
http://dx.doi.org/10.1155/2022/6116658
_version_ 1784787303215923200
author Lin, Weixun
Chen, Yaokun
Ji, Zeqi
Chen, Lingzhi
Wu, Jinyao
Chen, Yexi
Li, Zhiyang
author_facet Lin, Weixun
Chen, Yaokun
Ji, Zeqi
Chen, Lingzhi
Wu, Jinyao
Chen, Yexi
Li, Zhiyang
author_sort Lin, Weixun
collection PubMed
description Patients with a previous cancer history (PCA) are routinely excluded from most clinical trials, which may limit the accuracy and universality of clinical trials. We aimed to explore the association between PCA and survival of patients with different molecular subtypes of breast cancer. Patients diagnosed with breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015 were included in this retrospective cohort study. The primary outcome was overall survival (OS), which was calculated from date of diagnosis to date of death or censor date during this period. The relationship between PCA and OS of patients with different molecular subtypes of breast cancer was analyzed by the Kaplan-Meier curves and multivariate Cox proportional-hazards model. A total of 35,640 primary breast cancer patients were included, and 2,038 (5.72%) patients had a PCA. Female genital system cancer (491 cases, 24.09%) was the largest proportion type of previous cancer, and HER2-positive (24,754 cases, 69.46%) breast cancer was the most common subtype. Patients with previous female genital/endocrine system cancer history and other cancers history were associated with a poorer OS in overall patients, and in patients with triple-negative and HER2-positive subtypes (P < 0.05). In patients with Luminal A and Luminal B subtypes, previous other cancers history was related to poor OS (P < 0.05), while female genital/endocrine system cancer history may not influence the OS (P > 0.05). Subgroup analyses presented that PCA was related to poor OS in patients aged 40-64 years and ≥65 years (P <0.05), while prognosis in patients aged 18-40 years may not be influenced by PCA (P > 0.05). The impact of PCA on the prognosis of breast cancer patients was related to molecular type, patient age, and type of PCA. In clinical trials of breast cancer, the exclusion criteria for PCA patients may be modified according to the above variables.
format Online
Article
Text
id pubmed-9462974
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-94629742022-09-10 Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer Lin, Weixun Chen, Yaokun Ji, Zeqi Chen, Lingzhi Wu, Jinyao Chen, Yexi Li, Zhiyang Biomed Res Int Research Article Patients with a previous cancer history (PCA) are routinely excluded from most clinical trials, which may limit the accuracy and universality of clinical trials. We aimed to explore the association between PCA and survival of patients with different molecular subtypes of breast cancer. Patients diagnosed with breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015 were included in this retrospective cohort study. The primary outcome was overall survival (OS), which was calculated from date of diagnosis to date of death or censor date during this period. The relationship between PCA and OS of patients with different molecular subtypes of breast cancer was analyzed by the Kaplan-Meier curves and multivariate Cox proportional-hazards model. A total of 35,640 primary breast cancer patients were included, and 2,038 (5.72%) patients had a PCA. Female genital system cancer (491 cases, 24.09%) was the largest proportion type of previous cancer, and HER2-positive (24,754 cases, 69.46%) breast cancer was the most common subtype. Patients with previous female genital/endocrine system cancer history and other cancers history were associated with a poorer OS in overall patients, and in patients with triple-negative and HER2-positive subtypes (P < 0.05). In patients with Luminal A and Luminal B subtypes, previous other cancers history was related to poor OS (P < 0.05), while female genital/endocrine system cancer history may not influence the OS (P > 0.05). Subgroup analyses presented that PCA was related to poor OS in patients aged 40-64 years and ≥65 years (P <0.05), while prognosis in patients aged 18-40 years may not be influenced by PCA (P > 0.05). The impact of PCA on the prognosis of breast cancer patients was related to molecular type, patient age, and type of PCA. In clinical trials of breast cancer, the exclusion criteria for PCA patients may be modified according to the above variables. Hindawi 2022-09-02 /pmc/articles/PMC9462974/ /pubmed/36093405 http://dx.doi.org/10.1155/2022/6116658 Text en Copyright © 2022 Weixun Lin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Weixun
Chen, Yaokun
Ji, Zeqi
Chen, Lingzhi
Wu, Jinyao
Chen, Yexi
Li, Zhiyang
Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title_full Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title_fullStr Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title_full_unstemmed Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title_short Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
title_sort effect of previous cancer history on survival of patients with different subtypes of breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462974/
https://www.ncbi.nlm.nih.gov/pubmed/36093405
http://dx.doi.org/10.1155/2022/6116658
work_keys_str_mv AT linweixun effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT chenyaokun effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT jizeqi effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT chenlingzhi effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT wujinyao effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT chenyexi effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer
AT lizhiyang effectofpreviouscancerhistoryonsurvivalofpatientswithdifferentsubtypesofbreastcancer