Impact of TP53 mutations in Triple Negative Breast Cancer

Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may...

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Detalles Bibliográficos
Autores principales: Mitri, Zahi I., Abuhadra, Nour, Goodyear, Shaun M., Hobbs, Evthokia A., Kaempf, Andy, Thompson, Alastair M., Moulder, Stacy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463132/
https://www.ncbi.nlm.nih.gov/pubmed/36085319
http://dx.doi.org/10.1038/s41698-022-00303-6
Descripción
Sumario:Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.

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