Impact of TP53 mutations in Triple Negative Breast Cancer

Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may...

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Autores principales: Mitri, Zahi I., Abuhadra, Nour, Goodyear, Shaun M., Hobbs, Evthokia A., Kaempf, Andy, Thompson, Alastair M., Moulder, Stacy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463132/
https://www.ncbi.nlm.nih.gov/pubmed/36085319
http://dx.doi.org/10.1038/s41698-022-00303-6
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author Mitri, Zahi I.
Abuhadra, Nour
Goodyear, Shaun M.
Hobbs, Evthokia A.
Kaempf, Andy
Thompson, Alastair M.
Moulder, Stacy L.
author_facet Mitri, Zahi I.
Abuhadra, Nour
Goodyear, Shaun M.
Hobbs, Evthokia A.
Kaempf, Andy
Thompson, Alastair M.
Moulder, Stacy L.
author_sort Mitri, Zahi I.
collection PubMed
description Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.
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spelling pubmed-94631322022-09-11 Impact of TP53 mutations in Triple Negative Breast Cancer Mitri, Zahi I. Abuhadra, Nour Goodyear, Shaun M. Hobbs, Evthokia A. Kaempf, Andy Thompson, Alastair M. Moulder, Stacy L. NPJ Precis Oncol Brief Communication Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens. Nature Publishing Group UK 2022-09-09 /pmc/articles/PMC9463132/ /pubmed/36085319 http://dx.doi.org/10.1038/s41698-022-00303-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Mitri, Zahi I.
Abuhadra, Nour
Goodyear, Shaun M.
Hobbs, Evthokia A.
Kaempf, Andy
Thompson, Alastair M.
Moulder, Stacy L.
Impact of TP53 mutations in Triple Negative Breast Cancer
title Impact of TP53 mutations in Triple Negative Breast Cancer
title_full Impact of TP53 mutations in Triple Negative Breast Cancer
title_fullStr Impact of TP53 mutations in Triple Negative Breast Cancer
title_full_unstemmed Impact of TP53 mutations in Triple Negative Breast Cancer
title_short Impact of TP53 mutations in Triple Negative Breast Cancer
title_sort impact of tp53 mutations in triple negative breast cancer
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463132/
https://www.ncbi.nlm.nih.gov/pubmed/36085319
http://dx.doi.org/10.1038/s41698-022-00303-6
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