Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood...

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Detalles Bibliográficos
Autores principales: Sobral, Daniel, Martins, Marta, Kaplan, Shannon, Golkaram, Mahdi, Salmans, Michael, Khan, Nafeesa, Vijayaraghavan, Raakhee, Casimiro, Sandra, Fernandes, Afonso, Borralho, Paula, Ferreira, Cristina, Pinto, Rui, Abreu, Catarina, Costa, Ana Lúcia, Zhang, Shile, Pawlowski, Traci, Godsey, Jim, Mansinho, André, Macedo, Daniela, Lobo-Martins, Soraia, Filipe, Pedro, Esteves, Rui, Coutinho, João, Costa, Paulo Matos, Ramires, Afonso, Aldeia, Fernando, Quintela, António, So, Alex, Liu, Li, Grosso, Ana Rita, Costa, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463147/
https://www.ncbi.nlm.nih.gov/pubmed/36085309
http://dx.doi.org/10.1038/s42003-022-03884-x

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