A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

Glioblastoma is the most common adult brain tumour, representing a high degree of malignancy. Transcription factors such as RUNX1 are believed to be involved in the malignancy of glioblastoma. RUNX1 functions as an oncogene or tumour suppressor gene with diverse target genes. Details of the effects...

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Detalles Bibliográficos
Autores principales: Hattori, Etsuko Yamamoto, Masuda, Tatsuya, Mineharu, Yohei, Mikami, Masamitsu, Terada, Yukinori, Matsui, Yasuzumi, Kubota, Hirohito, Matsuo, Hidemasa, Hirata, Masahiro, Kataoka, Tatsuki R., Nakahata, Tatsutoshi, Ikeda, Shuji, Miyamoto, Susumu, Sugiyama, Hiroshi, Arakawa, Yoshiki, Kamikubo, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463152/
https://www.ncbi.nlm.nih.gov/pubmed/36085167
http://dx.doi.org/10.1038/s42003-022-03917-5

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