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Biofeedback electrostimulation for bionic and long-lasting neural modulation
Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and bui...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463164/ https://www.ncbi.nlm.nih.gov/pubmed/36085331 http://dx.doi.org/10.1038/s41467-022-33089-z |
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author | Jin, Fei Li, Tong Wei, Zhidong Xiong, Ruiying Qian, Lili Ma, Juan Yuan, Tao Wu, Qi Lai, Chengteng Ma, Xiying Wang, Fuyi Zhao, Ying Sun, Fengyu Wang, Ting Feng, Zhang-Qi |
author_facet | Jin, Fei Li, Tong Wei, Zhidong Xiong, Ruiying Qian, Lili Ma, Juan Yuan, Tao Wu, Qi Lai, Chengteng Ma, Xiying Wang, Fuyi Zhao, Ying Sun, Fengyu Wang, Ting Feng, Zhang-Qi |
author_sort | Jin, Fei |
collection | PubMed |
description | Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and built for bionic and long-lasting neural modulation. It can automatically yield biomimetic pulsed electrical signals under the driven of respiratory motion. These electrical signals are full of unique physiological synchronization can give biofeedback to respiratory behaviors, self-adjusting with different physiological states of the living body, and thus realizing a dynamic and biological self-matched modulation of voltage-gated calcium channels on the cell membrane. Abundant cellular and animal experimental evidence confirm an effective elimination of neural stimulus-inertia by these bioelectrical signals. An unprecedented nerve regeneration and motor functional reconstruction are achieved in long-segmental peripheral nerve defects, which is equal to the gold standard of nerve repair -- autograft. The wearable neural iES system provides an advanced platform to overcome the common neural stimulus-inertia and gives a broad avenue for personalized iES therapy of nerve injury and neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-9463164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94631642022-09-11 Biofeedback electrostimulation for bionic and long-lasting neural modulation Jin, Fei Li, Tong Wei, Zhidong Xiong, Ruiying Qian, Lili Ma, Juan Yuan, Tao Wu, Qi Lai, Chengteng Ma, Xiying Wang, Fuyi Zhao, Ying Sun, Fengyu Wang, Ting Feng, Zhang-Qi Nat Commun Article Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and built for bionic and long-lasting neural modulation. It can automatically yield biomimetic pulsed electrical signals under the driven of respiratory motion. These electrical signals are full of unique physiological synchronization can give biofeedback to respiratory behaviors, self-adjusting with different physiological states of the living body, and thus realizing a dynamic and biological self-matched modulation of voltage-gated calcium channels on the cell membrane. Abundant cellular and animal experimental evidence confirm an effective elimination of neural stimulus-inertia by these bioelectrical signals. An unprecedented nerve regeneration and motor functional reconstruction are achieved in long-segmental peripheral nerve defects, which is equal to the gold standard of nerve repair -- autograft. The wearable neural iES system provides an advanced platform to overcome the common neural stimulus-inertia and gives a broad avenue for personalized iES therapy of nerve injury and neurodegenerative diseases. Nature Publishing Group UK 2022-09-09 /pmc/articles/PMC9463164/ /pubmed/36085331 http://dx.doi.org/10.1038/s41467-022-33089-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jin, Fei Li, Tong Wei, Zhidong Xiong, Ruiying Qian, Lili Ma, Juan Yuan, Tao Wu, Qi Lai, Chengteng Ma, Xiying Wang, Fuyi Zhao, Ying Sun, Fengyu Wang, Ting Feng, Zhang-Qi Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title | Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title_full | Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title_fullStr | Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title_full_unstemmed | Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title_short | Biofeedback electrostimulation for bionic and long-lasting neural modulation |
title_sort | biofeedback electrostimulation for bionic and long-lasting neural modulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463164/ https://www.ncbi.nlm.nih.gov/pubmed/36085331 http://dx.doi.org/10.1038/s41467-022-33089-z |
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