Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates

We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed GO-2-Substrates, integrates protein function information, including GO terms from known substrates, with protein sequences to rank substrate candidates by similarity...

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Detalles Bibliográficos
Autores principales: Bell, Peter A., Scheuermann, Sophia, Renner, Florian, Pan, Christina L., Lu, Henry Y., Turvey, Stuart E., Bornancin, Frédéric, Régnier, Catherine H., Overall, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463181/
https://www.ncbi.nlm.nih.gov/pubmed/36147669
http://dx.doi.org/10.1016/j.csbj.2022.08.021

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