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A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders

Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miR...

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Autores principales: Abdolahi, Sara, Zare-Chahoki, Ameneh, Noorbakhsh, Farshid, Gorji, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463196/
https://www.ncbi.nlm.nih.gov/pubmed/35916975
http://dx.doi.org/10.1007/s12035-022-02966-5
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author Abdolahi, Sara
Zare-Chahoki, Ameneh
Noorbakhsh, Farshid
Gorji, Ali
author_facet Abdolahi, Sara
Zare-Chahoki, Ameneh
Noorbakhsh, Farshid
Gorji, Ali
author_sort Abdolahi, Sara
collection PubMed
description Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies.
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spelling pubmed-94631962022-09-11 A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders Abdolahi, Sara Zare-Chahoki, Ameneh Noorbakhsh, Farshid Gorji, Ali Mol Neurobiol Article Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies. Springer US 2022-08-02 2022 /pmc/articles/PMC9463196/ /pubmed/35916975 http://dx.doi.org/10.1007/s12035-022-02966-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Abdolahi, Sara
Zare-Chahoki, Ameneh
Noorbakhsh, Farshid
Gorji, Ali
A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title_full A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title_fullStr A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title_full_unstemmed A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title_short A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
title_sort review of molecular interplay between neurotrophins and mirnas in neuropsychological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463196/
https://www.ncbi.nlm.nih.gov/pubmed/35916975
http://dx.doi.org/10.1007/s12035-022-02966-5
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