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Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery

OBJECTIVE: To evaluate systolic flow-sensitive alternating inversion recovery (FAIR) during rest and exercise stress using 2RR (two cardiac cycles) or 1RR intervals between inversion pulse and imaging. MATERIALS AND METHODS: 1RR and 2RR FAIR was implemented on a 3T scanner. Ten healthy subjects were...

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Autores principales: Henningsson, Markus, Carlhäll, Carl-Johan, Ebbers, Tino, Kihlberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463284/
https://www.ncbi.nlm.nih.gov/pubmed/34958438
http://dx.doi.org/10.1007/s10334-021-00992-3
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author Henningsson, Markus
Carlhäll, Carl-Johan
Ebbers, Tino
Kihlberg, Johan
author_facet Henningsson, Markus
Carlhäll, Carl-Johan
Ebbers, Tino
Kihlberg, Johan
author_sort Henningsson, Markus
collection PubMed
description OBJECTIVE: To evaluate systolic flow-sensitive alternating inversion recovery (FAIR) during rest and exercise stress using 2RR (two cardiac cycles) or 1RR intervals between inversion pulse and imaging. MATERIALS AND METHODS: 1RR and 2RR FAIR was implemented on a 3T scanner. Ten healthy subjects were scanned during rest and stress. Stress was performed using an in-bore ergometer. Heart rate, mean myocardial blood flow (MBF) and temporal signal-to-noise ratio (TSNR) were compared using paired t tests. RESULTS: Mean heart rate during stress was higher than rest for 1RR FAIR (85.8 ± 13.7 bpm vs 63.3 ± 11.1 bpm; p < 0.01) and 2RR FAIR (83.8 ± 14.2 bpm vs 63.1 ± 10.6 bpm; p < 0.01). Mean stress MBF was higher than rest for 1RR FAIR (2.97 ± 0.76 ml/g/min vs 1.43 ± 0.6 ml/g/min; p < 0.01) and 2RR FAIR (2.8 ± 0.96 ml/g/min vs 1.22 ± 0.59 ml/g/min; p < 0.01). Resting mean MBF was higher for 1RR FAIR than 2RR FAIR (p < 0.05), but not during stress. TSNR was lower for stress compared to rest for 1RR FAIR (4.52 ± 2.54 vs 10.12 ± 3.69; p < 0.01) and 2RR FAIR (7.36 ± 3.78 vs 12.41 ± 5.12; p < 0.01). 2RR FAIR TSNR was higher than 1RR FAIR for rest (p < 0.05) and stress (p < 0.001). DISCUSSION: We have demonstrated feasibility of systolic FAIR in rest and exercise stress. 2RR delay systolic FAIR enables non-contrast perfusion assessment during stress with relatively high TSNR.
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spelling pubmed-94632842022-09-11 Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery Henningsson, Markus Carlhäll, Carl-Johan Ebbers, Tino Kihlberg, Johan MAGMA Research Article OBJECTIVE: To evaluate systolic flow-sensitive alternating inversion recovery (FAIR) during rest and exercise stress using 2RR (two cardiac cycles) or 1RR intervals between inversion pulse and imaging. MATERIALS AND METHODS: 1RR and 2RR FAIR was implemented on a 3T scanner. Ten healthy subjects were scanned during rest and stress. Stress was performed using an in-bore ergometer. Heart rate, mean myocardial blood flow (MBF) and temporal signal-to-noise ratio (TSNR) were compared using paired t tests. RESULTS: Mean heart rate during stress was higher than rest for 1RR FAIR (85.8 ± 13.7 bpm vs 63.3 ± 11.1 bpm; p < 0.01) and 2RR FAIR (83.8 ± 14.2 bpm vs 63.1 ± 10.6 bpm; p < 0.01). Mean stress MBF was higher than rest for 1RR FAIR (2.97 ± 0.76 ml/g/min vs 1.43 ± 0.6 ml/g/min; p < 0.01) and 2RR FAIR (2.8 ± 0.96 ml/g/min vs 1.22 ± 0.59 ml/g/min; p < 0.01). Resting mean MBF was higher for 1RR FAIR than 2RR FAIR (p < 0.05), but not during stress. TSNR was lower for stress compared to rest for 1RR FAIR (4.52 ± 2.54 vs 10.12 ± 3.69; p < 0.01) and 2RR FAIR (7.36 ± 3.78 vs 12.41 ± 5.12; p < 0.01). 2RR FAIR TSNR was higher than 1RR FAIR for rest (p < 0.05) and stress (p < 0.001). DISCUSSION: We have demonstrated feasibility of systolic FAIR in rest and exercise stress. 2RR delay systolic FAIR enables non-contrast perfusion assessment during stress with relatively high TSNR. Springer International Publishing 2021-12-27 2022 /pmc/articles/PMC9463284/ /pubmed/34958438 http://dx.doi.org/10.1007/s10334-021-00992-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Henningsson, Markus
Carlhäll, Carl-Johan
Ebbers, Tino
Kihlberg, Johan
Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title_full Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title_fullStr Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title_full_unstemmed Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title_short Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
title_sort non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463284/
https://www.ncbi.nlm.nih.gov/pubmed/34958438
http://dx.doi.org/10.1007/s10334-021-00992-3
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