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Advances in construction and modeling of functional neural circuits in vitro
Over the years, techniques have been developed to culture and assemble neurons, which brought us closer to creating neuronal circuits that functionally and structurally mimic parts of the brain. Starting with primary culture of neurons, preparations of neuronal culture have advanced substantially. D...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463289/ https://www.ncbi.nlm.nih.gov/pubmed/35943626 http://dx.doi.org/10.1007/s11064-022-03682-1 |
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author | Chow, Siu Yu A. Hu, Huaruo Osaki, Tatsuya Levi, Timothée Ikeuchi, Yoshiho |
author_facet | Chow, Siu Yu A. Hu, Huaruo Osaki, Tatsuya Levi, Timothée Ikeuchi, Yoshiho |
author_sort | Chow, Siu Yu A. |
collection | PubMed |
description | Over the years, techniques have been developed to culture and assemble neurons, which brought us closer to creating neuronal circuits that functionally and structurally mimic parts of the brain. Starting with primary culture of neurons, preparations of neuronal culture have advanced substantially. Development of stem cell research and brain organoids has opened a new path for generating three-dimensional human neural circuits. Along with the progress in biology, engineering technologies advanced and paved the way for construction of neural circuit structures. In this article, we overview research progress and discuss perspective of in vitro neural circuits and their ability and potential to acquire functions. Construction of in vitro neural circuits with complex higher-order functions would be achieved by converging development in diverse major disciplines including neuroscience, stem cell biology, tissue engineering, electrical engineering and computer science. |
format | Online Article Text |
id | pubmed-9463289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-94632892022-09-11 Advances in construction and modeling of functional neural circuits in vitro Chow, Siu Yu A. Hu, Huaruo Osaki, Tatsuya Levi, Timothée Ikeuchi, Yoshiho Neurochem Res Original Paper Over the years, techniques have been developed to culture and assemble neurons, which brought us closer to creating neuronal circuits that functionally and structurally mimic parts of the brain. Starting with primary culture of neurons, preparations of neuronal culture have advanced substantially. Development of stem cell research and brain organoids has opened a new path for generating three-dimensional human neural circuits. Along with the progress in biology, engineering technologies advanced and paved the way for construction of neural circuit structures. In this article, we overview research progress and discuss perspective of in vitro neural circuits and their ability and potential to acquire functions. Construction of in vitro neural circuits with complex higher-order functions would be achieved by converging development in diverse major disciplines including neuroscience, stem cell biology, tissue engineering, electrical engineering and computer science. Springer US 2022-08-09 2022 /pmc/articles/PMC9463289/ /pubmed/35943626 http://dx.doi.org/10.1007/s11064-022-03682-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Chow, Siu Yu A. Hu, Huaruo Osaki, Tatsuya Levi, Timothée Ikeuchi, Yoshiho Advances in construction and modeling of functional neural circuits in vitro |
title | Advances in construction and modeling of functional neural circuits in vitro |
title_full | Advances in construction and modeling of functional neural circuits in vitro |
title_fullStr | Advances in construction and modeling of functional neural circuits in vitro |
title_full_unstemmed | Advances in construction and modeling of functional neural circuits in vitro |
title_short | Advances in construction and modeling of functional neural circuits in vitro |
title_sort | advances in construction and modeling of functional neural circuits in vitro |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463289/ https://www.ncbi.nlm.nih.gov/pubmed/35943626 http://dx.doi.org/10.1007/s11064-022-03682-1 |
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