Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs

Endothelial progenitor cells (EPCs) are reduced in number and impaired in function in diabetic patients. Whether and how Nrf2 regulates the function of diabetic EPCs remains unclear. In this study, we found that the expression of Nrf2 and its downstream genes were decreased in EPCs from both diabeti...

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Detalles Bibliográficos
Autores principales: Dai, Xiaozhen, Wang, Kai, Fan, Jiawei, Liu, Hanjie, Fan, Xia, Lin, Qian, Chen, Yuhang, Chen, Hu, Li, Yao, Liu, Hairong, Chen, Oscar, Chen, Jing, Li, Xiaohong, Ren, Di, Li, Ji, Conklin, Daniel J., Wintergerst, Kupper A., Li, Yu, Cai, Lu, Deng, Zhongbin, Yan, Xiaoqing, Tan, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463384/
https://www.ncbi.nlm.nih.gov/pubmed/36063728
http://dx.doi.org/10.1016/j.redox.2022.102449

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