Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera

Antibody-drug conjugates (ADCs) are commonly heterogeneous and require extensive assessment of exposure-efficacy and exposure-safety relationships in preclinical and clinical studies. In this study, we report the generation of a monoclonal antibody against monomethyl auristatin E (MMAE) and the deve...

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Detalles Bibliográficos
Autores principales: Pei, Min, Liu, Tingting, Ouyang, Lu, Sun, Jianhua, Deng, Xiaojie, Sun, Xiaomin, Wu, Wei, Huang, Peng, Chen, Yi-Li, Tan, Xiaorong, Liu, Xiaoyue, Zhu, Peng, Liu, Yongzhen, Wang, Deheng, Wu, Junliang, Wang, Qi, Wang, Guifeng, Gong, Likun, Qin, Qiuping, Wang, Chunhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463470/
https://www.ncbi.nlm.nih.gov/pubmed/36105165
http://dx.doi.org/10.1016/j.jpha.2021.11.005

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