18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs

Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) is a natural compound that exists widely in herbal medicines, such as Glycyrrhiza uralensis Fisch, which is...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Luo, Piao, Zheng, Liuhai, Chen, Jiayun, Zhang, Junzhe, Tang, Huan, Liu, Dandan, He, Xueling, Shi, Qiaoli, Gu, Liwei, Li, Jiahao, Guo, Qiuyan, Yang, Chuanbin, Wong, Yin Kwan, Xia, Fei, Wang, Jigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463498/
https://www.ncbi.nlm.nih.gov/pubmed/36105163
http://dx.doi.org/10.1016/j.jpha.2022.06.001

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