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Simultaneous determination of LY3214996, abemaciclib, and M2 and M20 metabolites in human plasma, cerebrospinal fluid, and brain tumor by LC-MS/MS

A sensitive and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was established for the quantification of total and unbound concentrations of LY3214996, an extracellular signal-regulated kinase inhibitor; abemaciclib, a cyclin-dependent kinase 4/6 inhibitor; and abemaciclib ac...

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Detalles Bibliográficos
Autores principales:	Margaryan, Tigran, Elliott, Mackenna, Sanai, Nader, Tovmasyan, Artak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463526/ https://www.ncbi.nlm.nih.gov/pubmed/36105156 http://dx.doi.org/10.1016/j.jpha.2022.05.003

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