p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells

Despite recent advances in the development of BRAF kinase inhibitors (BRAFi) for BRAF-mutant melanomas, development of resistance remains a major clinical problem. In addition to genetic alterations associated with intrinsic resistance, several adaptive response mechanisms are known to be rapidly ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Pietrobono, Silvia, De Paolo, Raffaella, Mangiameli, Domenico, Marranci, Andrea, Battisti, Ilaria, Franchin, Cinzia, Arrigoni, Giorgio, Melisi, Davide, Poliseno, Laura, Stecca, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463537/
https://www.ncbi.nlm.nih.gov/pubmed/35944584
http://dx.doi.org/10.1016/j.jbc.2022.102353

Ejemplares similares

Ejemplares similares