Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters

Although chemotherapy induces complete remission in the majority of acute myeloid leukemia (AML) patients, many face a relapse. This relapse is caused by survival of chemotherapy-resistant leukemia (stem) cells (measurable residual disease; MRD). Here, we demonstrate that the anthracycline doxorubic...

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Detalles Bibliográficos
Autores principales: van Gils, Noortje, Verhagen, Han J.M.P., Broux, Michaël, Martiáñez, Tania, Denkers, Fedor, Vermue, Eline, Rutten, Arjo, Csikós, Tamás, Demeyer, Sofie, Çil, Meryem, Al, Marjon, Cools, Jan, Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., Menezes, Renee X., Smit, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463578/
https://www.ncbi.nlm.nih.gov/pubmed/36097617
http://dx.doi.org/10.1016/j.isci.2022.105013

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