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Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016

INTRODUCTION: In the Nordic countries, the use of mobile phones increased sharply in the mid-1990s especially among middle-aged men. We investigated time trends in glioma incidence rates (IR) with the perspective to inform about the plausibility of brain tumour risks from mobile phone use reported i...

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Autores principales: Deltour, Isabelle, Poulsen, Aslak Harbo, Johansen, Christoffer, Feychting, Maria, Johannesen, Tom Børge, Auvinen, Anssi, Schüz, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463632/
https://www.ncbi.nlm.nih.gov/pubmed/36041243
http://dx.doi.org/10.1016/j.envint.2022.107487
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author Deltour, Isabelle
Poulsen, Aslak Harbo
Johansen, Christoffer
Feychting, Maria
Johannesen, Tom Børge
Auvinen, Anssi
Schüz, Joachim
author_facet Deltour, Isabelle
Poulsen, Aslak Harbo
Johansen, Christoffer
Feychting, Maria
Johannesen, Tom Børge
Auvinen, Anssi
Schüz, Joachim
author_sort Deltour, Isabelle
collection PubMed
description INTRODUCTION: In the Nordic countries, the use of mobile phones increased sharply in the mid-1990s especially among middle-aged men. We investigated time trends in glioma incidence rates (IR) with the perspective to inform about the plausibility of brain tumour risks from mobile phone use reported in some case-control studies. METHODS: We analysed IR of glioma in Denmark, Finland, Norway, and Sweden among men aged 40–69 years, using data from national cancer registries and population statistics during 1979–2016, using log-linear joinpoint analysis. Information on regular mobile phone use and amount of call-time was obtained from major studies of mobile phones in these countries. We compared annual observed incidence with that expected under various risk scenarios to assess which of the reported effect sizes are compatible with the observed IR. The expected numbers of cases were computed accounting for an impact of other factors besides mobile phone use, such as improved cancer registration. RESULTS: Based on 18,232 glioma cases, IR increased slightly but steadily with a change of 0.1% (95 %CI 0.0%; 0.3%) per year during 1979–2016 among 40–59-year-old men and for ages 60–69, by 0.6 % (95 %CI 0.4; 0.9) annually. The observed IR trends among men aged 40–59 years were incompatible with risk ratios (RR) 1.08 or higher with a 10-year lag, RR ≥ 1.2 with 15-year lag and RR ≥ 1.5 with 20-year lag. For the age group 60–69 years, corresponding effect sizes RR ≥ 1.4, ≥2 and ≥ 2.5 could be rejected for lag times 10, 15 and 20 years. DISCUSSION: This study confirms and reinforces the conclusions that no changes in glioma incidence in the Nordic countries have occurred that are consistent with a substantial risk attributable to mobile phone use. This particularly applies to virtually all reported risk increases reported by previous case-control studies with positive findings.
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spelling pubmed-94636322022-10-01 Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016 Deltour, Isabelle Poulsen, Aslak Harbo Johansen, Christoffer Feychting, Maria Johannesen, Tom Børge Auvinen, Anssi Schüz, Joachim Environ Int Full Length Article INTRODUCTION: In the Nordic countries, the use of mobile phones increased sharply in the mid-1990s especially among middle-aged men. We investigated time trends in glioma incidence rates (IR) with the perspective to inform about the plausibility of brain tumour risks from mobile phone use reported in some case-control studies. METHODS: We analysed IR of glioma in Denmark, Finland, Norway, and Sweden among men aged 40–69 years, using data from national cancer registries and population statistics during 1979–2016, using log-linear joinpoint analysis. Information on regular mobile phone use and amount of call-time was obtained from major studies of mobile phones in these countries. We compared annual observed incidence with that expected under various risk scenarios to assess which of the reported effect sizes are compatible with the observed IR. The expected numbers of cases were computed accounting for an impact of other factors besides mobile phone use, such as improved cancer registration. RESULTS: Based on 18,232 glioma cases, IR increased slightly but steadily with a change of 0.1% (95 %CI 0.0%; 0.3%) per year during 1979–2016 among 40–59-year-old men and for ages 60–69, by 0.6 % (95 %CI 0.4; 0.9) annually. The observed IR trends among men aged 40–59 years were incompatible with risk ratios (RR) 1.08 or higher with a 10-year lag, RR ≥ 1.2 with 15-year lag and RR ≥ 1.5 with 20-year lag. For the age group 60–69 years, corresponding effect sizes RR ≥ 1.4, ≥2 and ≥ 2.5 could be rejected for lag times 10, 15 and 20 years. DISCUSSION: This study confirms and reinforces the conclusions that no changes in glioma incidence in the Nordic countries have occurred that are consistent with a substantial risk attributable to mobile phone use. This particularly applies to virtually all reported risk increases reported by previous case-control studies with positive findings. Elsevier Science 2022-10 /pmc/articles/PMC9463632/ /pubmed/36041243 http://dx.doi.org/10.1016/j.envint.2022.107487 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Full Length Article
Deltour, Isabelle
Poulsen, Aslak Harbo
Johansen, Christoffer
Feychting, Maria
Johannesen, Tom Børge
Auvinen, Anssi
Schüz, Joachim
Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title_full Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title_fullStr Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title_full_unstemmed Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title_short Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979–2016
title_sort time trends in mobile phone use and glioma incidence among males in the nordic countries, 1979–2016
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463632/
https://www.ncbi.nlm.nih.gov/pubmed/36041243
http://dx.doi.org/10.1016/j.envint.2022.107487
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