Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

BACKGROUND: SMAD4 is a key mediator of TGFβ signaling and one of the mutated genes in extrahepatic bile duct cancer (eBDC). It has been also reported that SMAD4 has dual functions, in carcinogenesis via silencing and in tumor invasion/metastasis via signaling, depending on tumor stage. We previously...

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Detalles Bibliográficos
Autores principales: Takayama, Hirotoshi, Kobayashi, Shogo, Gotoh, Kunihito, Sasaki, Kazuki, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Wada, Hiroshi, Takahashi, Hidenori, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463834/
https://www.ncbi.nlm.nih.gov/pubmed/36088360
http://dx.doi.org/10.1186/s12957-022-02747-3

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