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Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population

BACKGROUND: Perfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs wi...

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Autores principales: Li, Xuejun, Song, Fengju, Liu, Xiaotu, Shan, Anqi, Huang, Yubei, Yang, Zhengjun, Li, Haixin, Yang, Qiaoyun, Yu, Yue, Zheng, Hong, Cao, Xu-Chen, Chen, Da, Chen, Ke-Xin, Chen, Xi, Tang, Nai-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463854/
https://www.ncbi.nlm.nih.gov/pubmed/36085159
http://dx.doi.org/10.1186/s12940-022-00895-3
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author Li, Xuejun
Song, Fengju
Liu, Xiaotu
Shan, Anqi
Huang, Yubei
Yang, Zhengjun
Li, Haixin
Yang, Qiaoyun
Yu, Yue
Zheng, Hong
Cao, Xu-Chen
Chen, Da
Chen, Ke-Xin
Chen, Xi
Tang, Nai-jun
author_facet Li, Xuejun
Song, Fengju
Liu, Xiaotu
Shan, Anqi
Huang, Yubei
Yang, Zhengjun
Li, Haixin
Yang, Qiaoyun
Yu, Yue
Zheng, Hong
Cao, Xu-Chen
Chen, Da
Chen, Ke-Xin
Chen, Xi
Tang, Nai-jun
author_sort Li, Xuejun
collection PubMed
description BACKGROUND: Perfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs with respect to breast cancer in the Chinese population. METHODS: Participants who were initially diagnosed with breast cancer at Tianjin Medical University Cancer Institute and Hospital between 2012 and 2016 were recruited as cases. The controls were randomly selected from the participants with available blood samples in the Chinese National Breast Cancer Screening Program (CNBCSP) cohort. Ultimately, we enrolled 373 breast cancer patients and 657 controls. Plasma PFASs were measured by an ultra-performance liquid chromatography (UPLC) system coupled to a 5500 Q-Trap triple quadrupole mass spectrometer. A logistic regression model with least absolute shrinkage and selection operator (LASSO) regularization was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationships between PFASs and breast cancer. The three most predictive variables in the LASSO model were selected from 17 PFASs, which was based on the optimal penalty coefficient (λ = 0.0218) identified with the minimum criterion. Additionally, Bayesian kernel machine regression (BKMR) and quantile g-computation models were applied to evaluate the associations between separate and mixed exposure to PFASs and breast cancer. RESULTS: Perfluorooctanesulfonic acid (PFOS) exhibited the highest concentration in both the cases and controls. Perfluorooctanoic acid (PFOA) and perfluoro-n-decanoic acid (PFDA) were positively associated with breast cancer, and perfluoro-n-tridecanoic acid (PFTrDA) was negatively associated with breast cancer according to both the continuous-PFASs and the quartile-PFASs logistic regression models. Of note, PFOA was associated with the occurrence of estrogen receptor (ER)-, progesterone receptor (PR)-, and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (OR(ER+)  = 1.47, 95% CI: 1.19, 1.80; OR(PR+)  = 1.36, 95% CI: 1.09, 1.69; OR(HER2) = 1.62, 95% CI: 1.19, 2.21). CONCLUSIONS: Overall, we observed that PFASs were associated with breast cancer in Chinese women. Prospective cohort studies and mechanistic experiments are warranted to elucidate whether these associations are causal. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12940-022-00895-3.
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spelling pubmed-94638542022-09-11 Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population Li, Xuejun Song, Fengju Liu, Xiaotu Shan, Anqi Huang, Yubei Yang, Zhengjun Li, Haixin Yang, Qiaoyun Yu, Yue Zheng, Hong Cao, Xu-Chen Chen, Da Chen, Ke-Xin Chen, Xi Tang, Nai-jun Environ Health Research BACKGROUND: Perfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs with respect to breast cancer in the Chinese population. METHODS: Participants who were initially diagnosed with breast cancer at Tianjin Medical University Cancer Institute and Hospital between 2012 and 2016 were recruited as cases. The controls were randomly selected from the participants with available blood samples in the Chinese National Breast Cancer Screening Program (CNBCSP) cohort. Ultimately, we enrolled 373 breast cancer patients and 657 controls. Plasma PFASs were measured by an ultra-performance liquid chromatography (UPLC) system coupled to a 5500 Q-Trap triple quadrupole mass spectrometer. A logistic regression model with least absolute shrinkage and selection operator (LASSO) regularization was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationships between PFASs and breast cancer. The three most predictive variables in the LASSO model were selected from 17 PFASs, which was based on the optimal penalty coefficient (λ = 0.0218) identified with the minimum criterion. Additionally, Bayesian kernel machine regression (BKMR) and quantile g-computation models were applied to evaluate the associations between separate and mixed exposure to PFASs and breast cancer. RESULTS: Perfluorooctanesulfonic acid (PFOS) exhibited the highest concentration in both the cases and controls. Perfluorooctanoic acid (PFOA) and perfluoro-n-decanoic acid (PFDA) were positively associated with breast cancer, and perfluoro-n-tridecanoic acid (PFTrDA) was negatively associated with breast cancer according to both the continuous-PFASs and the quartile-PFASs logistic regression models. Of note, PFOA was associated with the occurrence of estrogen receptor (ER)-, progesterone receptor (PR)-, and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (OR(ER+)  = 1.47, 95% CI: 1.19, 1.80; OR(PR+)  = 1.36, 95% CI: 1.09, 1.69; OR(HER2) = 1.62, 95% CI: 1.19, 2.21). CONCLUSIONS: Overall, we observed that PFASs were associated with breast cancer in Chinese women. Prospective cohort studies and mechanistic experiments are warranted to elucidate whether these associations are causal. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12940-022-00895-3. BioMed Central 2022-09-09 /pmc/articles/PMC9463854/ /pubmed/36085159 http://dx.doi.org/10.1186/s12940-022-00895-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Xuejun
Song, Fengju
Liu, Xiaotu
Shan, Anqi
Huang, Yubei
Yang, Zhengjun
Li, Haixin
Yang, Qiaoyun
Yu, Yue
Zheng, Hong
Cao, Xu-Chen
Chen, Da
Chen, Ke-Xin
Chen, Xi
Tang, Nai-jun
Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title_full Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title_fullStr Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title_full_unstemmed Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title_short Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
title_sort perfluoroalkyl substances (pfass) as risk factors for breast cancer: a case–control study in chinese population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463854/
https://www.ncbi.nlm.nih.gov/pubmed/36085159
http://dx.doi.org/10.1186/s12940-022-00895-3
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