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Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study

Herbs and hand-made herbal remedies have been long used for disease control, treatment, and health improvement. Evidence suggests that a single herb’s compounds can have synergistic functions with probably no adverse effect. Unfortunately, the traditional administration of essential oil (EO) does no...

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Autores principales: Taherian, Pouria, Nourbakhsh, Mohammad Sadegh, Mehrizi, Ali Abouei, Hashemi, Mohadeseh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Fiber Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464059/
http://dx.doi.org/10.1007/s12221-022-4937-y
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author Taherian, Pouria
Nourbakhsh, Mohammad Sadegh
Mehrizi, Ali Abouei
Hashemi, Mohadeseh
author_facet Taherian, Pouria
Nourbakhsh, Mohammad Sadegh
Mehrizi, Ali Abouei
Hashemi, Mohadeseh
author_sort Taherian, Pouria
collection PubMed
description Herbs and hand-made herbal remedies have been long used for disease control, treatment, and health improvement. Evidence suggests that a single herb’s compounds can have synergistic functions with probably no adverse effect. Unfortunately, the traditional administration of essential oil (EO) does not follow a regulatory dose regimen, causing reduced bioavailability due to EO evaporation or denaturation in harsh biological environments. Hence, encapsulation can help enhance EO stability and dose dependence. Here, chitosan nanoparticles (ChNPs) were used to encapsulate frankincense essential oil (FEO) to preserve its remarkable therapeutic effects. Also, traditional bulk preparation methods were compared with microfluidic with central aqueous stream configuration (CAS). The results indicated the higher quality of microfluidic-based nanoparticles with uniform, spherical, and separated morphologies. The size of bulk and microfluidic nanoparticles ranged from 86 to 118 nm, the surface charge varied from 12.5 to 19.5 for different amounts of FEO, and the as-prepared colloid remained stable for three days. Narrow size distribution (PDI≤0.28) and high encapsulation efficiency (EE≤99 %) were achieved using the microfluidic process compared to the bulk method (PDI=0.74, EE≤90 %). The microfluidic nanoparticle also indicated a burst release rate greater than the bulk method (≤30 %). It was concluded that the high-performance microfluidic approach provided higher quality and more control over nanoparticle properties.
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spelling pubmed-94640592022-09-12 Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study Taherian, Pouria Nourbakhsh, Mohammad Sadegh Mehrizi, Ali Abouei Hashemi, Mohadeseh Fibers Polym Article Herbs and hand-made herbal remedies have been long used for disease control, treatment, and health improvement. Evidence suggests that a single herb’s compounds can have synergistic functions with probably no adverse effect. Unfortunately, the traditional administration of essential oil (EO) does not follow a regulatory dose regimen, causing reduced bioavailability due to EO evaporation or denaturation in harsh biological environments. Hence, encapsulation can help enhance EO stability and dose dependence. Here, chitosan nanoparticles (ChNPs) were used to encapsulate frankincense essential oil (FEO) to preserve its remarkable therapeutic effects. Also, traditional bulk preparation methods were compared with microfluidic with central aqueous stream configuration (CAS). The results indicated the higher quality of microfluidic-based nanoparticles with uniform, spherical, and separated morphologies. The size of bulk and microfluidic nanoparticles ranged from 86 to 118 nm, the surface charge varied from 12.5 to 19.5 for different amounts of FEO, and the as-prepared colloid remained stable for three days. Narrow size distribution (PDI≤0.28) and high encapsulation efficiency (EE≤99 %) were achieved using the microfluidic process compared to the bulk method (PDI=0.74, EE≤90 %). The microfluidic nanoparticle also indicated a burst release rate greater than the bulk method (≤30 %). It was concluded that the high-performance microfluidic approach provided higher quality and more control over nanoparticle properties. The Korean Fiber Society 2022-09-10 2022 /pmc/articles/PMC9464059/ http://dx.doi.org/10.1007/s12221-022-4937-y Text en © The Korean Fiber Society for Fibers and Polymers and Springer 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Taherian, Pouria
Nourbakhsh, Mohammad Sadegh
Mehrizi, Ali Abouei
Hashemi, Mohadeseh
Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title_full Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title_fullStr Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title_full_unstemmed Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title_short Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
title_sort encapsulation of frankincense essential oil by microfluidic and bulk approaches: a comparative study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464059/
http://dx.doi.org/10.1007/s12221-022-4937-y
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