Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-pro...

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Detalles Bibliográficos
Autores principales: Petrosyan, Varduhi, Dobrolecki, Lacey E., LaPlante, Emily L., Srinivasan, Ramakrishnan Rajaram, Bailey, Matthew H., Welm, Alana L., Welm, Bryan E., Lewis, Michael T., Milosavljevic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464188/
https://www.ncbi.nlm.nih.gov/pubmed/36088362
http://dx.doi.org/10.1038/s41523-022-00476-0
Descripción
Sumario:TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment.

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