Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrosyan, Varduhi, Dobrolecki, Lacey E., LaPlante, Emily L., Srinivasan, Ramakrishnan Rajaram, Bailey, Matthew H., Welm, Alana L., Welm, Bryan E., Lewis, Michael T., Milosavljevic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464188/
https://www.ncbi.nlm.nih.gov/pubmed/36088362
http://dx.doi.org/10.1038/s41523-022-00476-0
_version_ 1784787528363016192
author Petrosyan, Varduhi
Dobrolecki, Lacey E.
LaPlante, Emily L.
Srinivasan, Ramakrishnan Rajaram
Bailey, Matthew H.
Welm, Alana L.
Welm, Bryan E.
Lewis, Michael T.
Milosavljevic, Aleksandar
author_facet Petrosyan, Varduhi
Dobrolecki, Lacey E.
LaPlante, Emily L.
Srinivasan, Ramakrishnan Rajaram
Bailey, Matthew H.
Welm, Alana L.
Welm, Bryan E.
Lewis, Michael T.
Milosavljevic, Aleksandar
author_sort Petrosyan, Varduhi
collection PubMed
description TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment.
format Online
Article
Text
id pubmed-9464188
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-94641882022-09-12 Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts Petrosyan, Varduhi Dobrolecki, Lacey E. LaPlante, Emily L. Srinivasan, Ramakrishnan Rajaram Bailey, Matthew H. Welm, Alana L. Welm, Bryan E. Lewis, Michael T. Milosavljevic, Aleksandar NPJ Breast Cancer Brief Communication TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment. Nature Publishing Group UK 2022-09-10 /pmc/articles/PMC9464188/ /pubmed/36088362 http://dx.doi.org/10.1038/s41523-022-00476-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Petrosyan, Varduhi
Dobrolecki, Lacey E.
LaPlante, Emily L.
Srinivasan, Ramakrishnan Rajaram
Bailey, Matthew H.
Welm, Alana L.
Welm, Bryan E.
Lewis, Michael T.
Milosavljevic, Aleksandar
Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title_full Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title_fullStr Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title_full_unstemmed Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title_short Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
title_sort immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464188/
https://www.ncbi.nlm.nih.gov/pubmed/36088362
http://dx.doi.org/10.1038/s41523-022-00476-0
work_keys_str_mv AT petrosyanvarduhi immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT dobroleckilaceye immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT laplanteemilyl immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT srinivasanramakrishnanrajaram immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT baileymatthewh immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT welmalanal immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT welmbryane immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT lewismichaelt immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts
AT milosavljevicaleksandar immunologicallycoldtriplenegativebreastcancersengraftatahigherrateinpatientderivedxenografts

Ejemplares similares