Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic α-synuclein (αSyn) aggregate/oligomer accumulation. LRRK2 hyperactivity is a disease-modifying therapeutic target in PD. However, LRRK2 inhibition may be...

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Detalles Bibliográficos
Autores principales: Ho, Philip Wing-Lok, Chang, Eunice Eun-Seo, Leung, Chi-Ting, Liu, Huifang, Malki, Yasine, Pang, Shirley Yin-Yu, Choi, Zoe Yuen-Kiu, Liang, Yingmin, Lai, Weng Seng, Ruan, Yuefei, Leung, Kenneth Mei-Yee, Yung, Susan, Mak, Judith Choi-Wo, Kung, Michelle Hiu-Wai, Ramsden, David B., Ho, Shu-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464237/
https://www.ncbi.nlm.nih.gov/pubmed/36088364
http://dx.doi.org/10.1038/s41531-022-00386-9

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