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Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes
Here we present an exome-wide rare genetic variant association study for 30 blood biomarkers in 191,971 individuals in the UK Biobank. We compare gene-based association tests for separate functional variant categories to increase interpretability and identify 193 significant gene-biomarker associati...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464252/ https://www.ncbi.nlm.nih.gov/pubmed/36088354 http://dx.doi.org/10.1038/s41467-022-32864-2 |