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COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series

Mucormycosis is a disease that usually occurs in immunocompromised patients or those with uncontrolled diabetes mellitus. The second wave of the coronavirus disease 2019 (COVID-19) pandemic in India was accompanied by an unexpected rise in mucormycosis cases, ranging from the most commonly occurring...

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Autores principales: Singh, Shivam, Basera, Pragati, Anand, Aditya, Ozair, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464320/
https://www.ncbi.nlm.nih.gov/pubmed/36110469
http://dx.doi.org/10.7759/cureus.27906
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author Singh, Shivam
Basera, Pragati
Anand, Aditya
Ozair, Ahmad
author_facet Singh, Shivam
Basera, Pragati
Anand, Aditya
Ozair, Ahmad
author_sort Singh, Shivam
collection PubMed
description Mucormycosis is a disease that usually occurs in immunocompromised patients or those with uncontrolled diabetes mellitus. The second wave of the coronavirus disease 2019 (COVID-19) pandemic in India was accompanied by an unexpected rise in mucormycosis cases, ranging from the most commonly occurring Rhino-orbital-cerebral mucormycosis (ROCM) to rare cases of pulmonary and gastrointestinal mucormycosis. The majority of cases that presented to our hospital were individuals with underlying diabetes mellitus who received steroids for COVID-19 before being diagnosed with mucormycosis. In this case series, we present five rhino-orbital-cerebral mucormycosis cases that were histopathologically positive and treated at a tertiary-care hospital in India. Magnetic resonance imaging (MRI) of all of the patients demonstrated orbital apex syndrome and diffuse or focal infiltration of the cavernous sinus. Cases were treated with anti-fungal drugs, transcutaneous retrobulbar injection of amphotericin B (TRAM B), along with appropriate surgical excision and debridement of the involved tissue. The essential elements for successfully managing this fatal infection are control of the predisposing factors, early detection, anti-fungal drugs, and surgical debridement of the involved tissues.
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spelling pubmed-94643202022-09-14 COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series Singh, Shivam Basera, Pragati Anand, Aditya Ozair, Ahmad Cureus Internal Medicine Mucormycosis is a disease that usually occurs in immunocompromised patients or those with uncontrolled diabetes mellitus. The second wave of the coronavirus disease 2019 (COVID-19) pandemic in India was accompanied by an unexpected rise in mucormycosis cases, ranging from the most commonly occurring Rhino-orbital-cerebral mucormycosis (ROCM) to rare cases of pulmonary and gastrointestinal mucormycosis. The majority of cases that presented to our hospital were individuals with underlying diabetes mellitus who received steroids for COVID-19 before being diagnosed with mucormycosis. In this case series, we present five rhino-orbital-cerebral mucormycosis cases that were histopathologically positive and treated at a tertiary-care hospital in India. Magnetic resonance imaging (MRI) of all of the patients demonstrated orbital apex syndrome and diffuse or focal infiltration of the cavernous sinus. Cases were treated with anti-fungal drugs, transcutaneous retrobulbar injection of amphotericin B (TRAM B), along with appropriate surgical excision and debridement of the involved tissue. The essential elements for successfully managing this fatal infection are control of the predisposing factors, early detection, anti-fungal drugs, and surgical debridement of the involved tissues. Cureus 2022-08-11 /pmc/articles/PMC9464320/ /pubmed/36110469 http://dx.doi.org/10.7759/cureus.27906 Text en Copyright © 2022, Singh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Singh, Shivam
Basera, Pragati
Anand, Aditya
Ozair, Ahmad
COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title_full COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title_fullStr COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title_full_unstemmed COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title_short COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series
title_sort covid-19-associated mucormycosis in a tertiary care hospital in india: a case series
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464320/
https://www.ncbi.nlm.nih.gov/pubmed/36110469
http://dx.doi.org/10.7759/cureus.27906
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