Effect of Genetic Variations in the ADIPOQ Gene on Susceptibility to Type 2 Diabetes Mellitus

BACKGROUND: ADIPOQ (adiponectin) affects fatty acid oxidation, glucose uptake, and glycogenesis, all of which are involved in the development of diabetes. As a result, ADIPOQ is being studied as a potential gene for type 2 diabetes mellitus (T2DM), which is a polygenic disease with genetic inheritance. This study aims to investigate the genetic variants (rs17846866 and rs1501299) in ADIPOQ gene with T2DM in the Saudi population. METHODS: In this study, T2DM patients (n=96) and healthy controls (n=96) were recruited for molecular analysis for rs17846866 and rs1501299 single nucleotide polymorphisms (SNPs). Clinical data were analyzed using t-tests, HWE analysis, and genotype and allele frequencies were calculated for the rs17846866 and rs1501299 SNPs between T2DM cases and controls. ANOVA analysis was also used to investigate the relationship between the SNPs rs17846866 and rs1501299 and T2DM characteristics. RESULTS: The current study results confirmed a positive association between clinical characteristics, HWE analysis, genotype, and allele frequencies in both rs17846466 and rs1501299 SNPs (p<0.05). In T2DM patients, ANOVA analysis with rs17846466 and rs1501299 SNPs in the ADIPOQ gene has no effect on any of the involved parameters (p>0.05). CONCLUSION: This study concludes as rs17846866 and rs1501299 SNPs were strongly associated in the Saudi population with T2DM patients.