Cargando…

Primitive genotypic characteristics in umbilical cord neutrophils identified by single-cell transcriptome profiling and functional prediction

The function and heterogeneity of neutrophils in neonatal umbilical cord blood (UCB) have not been characterized. In this study, we analyzed the neutrophils in UCB and healthy adults using single-cell RNA sequencing analysis for the first time. We found that neutrophils divided into six subpopulatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yi, Huang, Jiamin, Guo, Zaiwen, Zhu, Zhechen, Shao, Yiming, Li, Linbin, Yang, Yunxi, Yu, Yanzhen, Liu, Lu, Sun, Bingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464600/ https://www.ncbi.nlm.nih.gov/pubmed/36105817 http://dx.doi.org/10.3389/fimmu.2022.970909

Ejemplares similares

Single-Cell Transcriptome Profiling Reveals Neutrophil Heterogeneity and Functional Multiplicity in the Early Stage of Severe Burn Patients
por: Huang, Jiamin, et al.
Publicado: (2022)

Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway
por: Shao, Yiming, et al.
Publicado: (2022)

A novel computer vision‐based assessment of neutrophil chemotaxis in patients with severe infection
por: Yang, Yunxi, et al.
Publicado: (2021)

CD44/ERM/F‐actin complex mediates targeted nuclear degranulation and excessive neutrophil extracellular trap formation during sepsis
por: Shao, Yiming, et al.
Publicado: (2022)

Dysfunction of low-density neutrophils in peripheral circulation in patients with sepsis
por: Sun, Ran, et al.
Publicado: (2022)

Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns (With video)
por: Liu, Lu, et al.
Publicado: (2021)

An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy
por: Yu, Yanzhen, et al.
Publicado: (2023)

Identification and characterization of neutrophil heterogeneity in sepsis
por: Qi, Xinxin, et al.
Publicado: (2021)

Prospective study and validation of early warning marker discovery based on integrating multi-omics analysis in severe burn patients with sepsis
por: Huang, Jiamin, et al.
Publicado: (2023)

Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
por: Sarvaria, Anushruti, et al.
Publicado: (2017)

Improving Engraftment and Immune Reconstitution in Umbilical Cord Blood Transplantation
por: Danby, Robert, et al.
Publicado: (2014)

Integrated Analysis of Transcriptome and Secretome From Umbilical Cord Mesenchymal Stromal Cells Reveal New Mechanisms for the Modulation of Inflammation and Immune Activation
por: Cruz-Barrera, Mónica, et al.
Publicado: (2020)

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
por: Almamun, Md, et al.
Publicado: (2013)

Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single-cell RNA sequencing
por: Liu, Yuanyuan, et al.
Publicado: (2023)

Corrigendum: Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single-cell RNA sequencing
por: Liu, Yuanyuan, et al.
Publicado: (2023)

Transcriptomic Profiling Identifies Neutrophil-Specific Upregulation of Cystatin F as a Marker of Acute Inflammation in Humans
por: Sawyer, Andrew J., et al.
Publicado: (2021)

Modeling Human Antitumor Responses In Vivo Using Umbilical Cord Blood-Engrafted Mice
por: Zumwalde, Nicholas A., et al.
Publicado: (2018)

Evaluation of preclinical efficacy of human umbilical cord mesenchymal stem cells in ankylosing spondylitis
por: Shen, Danpeng, et al.
Publicado: (2023)

The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages
por: Ó Maoldomhnaigh, Cilian, et al.
Publicado: (2021)

Pre-clinical efficacy evaluation of human umbilical cord mesenchymal stem cells for ischemic stroke
por: Shen, Danpeng, et al.
Publicado: (2023)

Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4(+) T cells
por: Sengun, Ezgi, et al.
Publicado: (2023)

Interaction of the Macrophage and Primitive Erythroid Lineages in the Mammalian Embryo
por: Palis, James
Publicado: (2017)

Efficacy of umbilical cord mesenchymal stromal cells for COVID-19: A systematic review and meta-analysis
por: Yang, Cong-wen, et al.
Publicado: (2022)

Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units
por: Patterson, John, et al.
Publicado: (2015)

In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer
por: Veluchamy, John P., et al.
Publicado: (2017)

Functional Characterisation and Analysis of the Soluble NKG2D Ligand Repertoire Detected in Umbilical Cord Blood Plasma
por: Cox, Steven T., et al.
Publicado: (2018)

Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
por: Nguyen, Thu Huyen, et al.
Publicado: (2022)

The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis
por: Miranda, Joana P., et al.
Publicado: (2019)

Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire
por: Gao, Kai, et al.
Publicado: (2019)

Corrigendum: Functional Characterisation and Analysis of the Soluble NKG2D Ligand Repertoire Detected in Umbilical Cord Blood Plasma
por: Cox, Steven T., et al.
Publicado: (2020)

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice
por: Lu, XiaoJuan, et al.
Publicado: (2022)

Diversity of dendritic cells generated from umbilical cord or adult peripheral blood precursors
por: Szaryńska, Magdalena, et al.
Publicado: (2018)

Identifying neutrophil-associated subtypes in ulcerative colitis and confirming neutrophils promote colitis-associated colorectal cancer
por: Zhang, Chen, et al.
Publicado: (2023)

Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood–Spinal Cord Barrier Disruption in Spinal Cord Injury
por: Feng, Zhou, et al.
Publicado: (2021)

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
por: Huls, M. Helen, et al.
Publicado: (2013)

Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
por: Goldenson, Benjamin H., et al.
Publicado: (2020)

Corrigendum: Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire
por: Gao, Kai, et al.
Publicado: (2020)

Case Report: Analysis of Preserved Umbilical Cord Clarified X-Linked Anhidrotic Ectodermal Dysplasia With Immunodeficiency in Deceased, Undiagnosed Uncles
por: Inaba, Satoshi, et al.
Publicado: (2021)

Proteomic and phosphorylated proteomic landscape of injured lung in juvenile septic rats with therapeutic application of umbilical cord mesenchymal stem cells
por: Wang, Hongwu, et al.
Publicado: (2022)

Pregnancy and umbilical cord pathology: structural and functional parameters of the umbilical cord
por: Dubetskyi, Bohdan Ihorovych, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rol9qbo08mvh7dts1jhph7em2l