Cargando…

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

BACKGROUND: The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. METHODS: In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synt...

Descripción completa

Detalles Bibliográficos
Autores principales: Niu, Jiangxiu, Yuan, Ming, Zhang, Zhaowei, Wang, Liye, Fan, Yanli, Liu, Xianghui, Liu, Xianming, Ya, Huiyuan, Zhang, Yansong, Xu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464638/
https://www.ncbi.nlm.nih.gov/pubmed/36105622
http://dx.doi.org/10.2147/IJN.S372711
_version_ 1784787627626463232
author Niu, Jiangxiu
Yuan, Ming
Zhang, Zhaowei
Wang, Liye
Fan, Yanli
Liu, Xianghui
Liu, Xianming
Ya, Huiyuan
Zhang, Yansong
Xu, Yang
author_facet Niu, Jiangxiu
Yuan, Ming
Zhang, Zhaowei
Wang, Liye
Fan, Yanli
Liu, Xianghui
Liu, Xianming
Ya, Huiyuan
Zhang, Yansong
Xu, Yang
author_sort Niu, Jiangxiu
collection PubMed
description BACKGROUND: The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. METHODS: In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized by amide reaction technique to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. CUR-M was successfully prepared by dialysis, and the formulation was evaluated for particle size, zeta potential, surface morphology, entrapment effciency (EE%), drug loading (DL), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and the in vitro drug release. Additionally, in vitro skin permeation and retention, in vivo topical analgesic and anti-inflammatory activity, and skin irritation were assessed. RESULTS: The mean drug loading (DL), drug entrapment efficiency (EE), hydrodynamic diameter and zeta potential of CUR-M were 8.26%, 90.86%, 165.64 nm and −26.85 mV, respectively. CUR-M was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), it was found that there was an interaction between CUR and OHA, and CUR existed in CUR-M in an amorphous form. CUR-M exhibited sustained release in 48 h and good stability at 4 °C for 21days. CUR-M could significantly increase the skin penetration and retention of CUR and had better analgesic and anti-inflammatory activities in vivo when compared with CUR solution. Hematoxylin-eosin staining results revealed that the transdermal penetration mechanism of CUR-M might be related to the hydration of stratum corneum by HA. In addition, CUR-M showed no skin irritation to mouse skin. CONCLUSION: CUR-M might be a promising and safe drug delivery system for the treatment of topical diseases.
format Online
Article
Text
id pubmed-9464638
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-94646382022-09-13 Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin Niu, Jiangxiu Yuan, Ming Zhang, Zhaowei Wang, Liye Fan, Yanli Liu, Xianghui Liu, Xianming Ya, Huiyuan Zhang, Yansong Xu, Yang Int J Nanomedicine Original Research BACKGROUND: The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. METHODS: In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized by amide reaction technique to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. CUR-M was successfully prepared by dialysis, and the formulation was evaluated for particle size, zeta potential, surface morphology, entrapment effciency (EE%), drug loading (DL), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and the in vitro drug release. Additionally, in vitro skin permeation and retention, in vivo topical analgesic and anti-inflammatory activity, and skin irritation were assessed. RESULTS: The mean drug loading (DL), drug entrapment efficiency (EE), hydrodynamic diameter and zeta potential of CUR-M were 8.26%, 90.86%, 165.64 nm and −26.85 mV, respectively. CUR-M was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), it was found that there was an interaction between CUR and OHA, and CUR existed in CUR-M in an amorphous form. CUR-M exhibited sustained release in 48 h and good stability at 4 °C for 21days. CUR-M could significantly increase the skin penetration and retention of CUR and had better analgesic and anti-inflammatory activities in vivo when compared with CUR solution. Hematoxylin-eosin staining results revealed that the transdermal penetration mechanism of CUR-M might be related to the hydration of stratum corneum by HA. In addition, CUR-M showed no skin irritation to mouse skin. CONCLUSION: CUR-M might be a promising and safe drug delivery system for the treatment of topical diseases. Dove 2022-09-07 /pmc/articles/PMC9464638/ /pubmed/36105622 http://dx.doi.org/10.2147/IJN.S372711 Text en © 2022 Niu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Niu, Jiangxiu
Yuan, Ming
Zhang, Zhaowei
Wang, Liye
Fan, Yanli
Liu, Xianghui
Liu, Xianming
Ya, Huiyuan
Zhang, Yansong
Xu, Yang
Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title_full Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title_fullStr Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title_full_unstemmed Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title_short Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin
title_sort hyaluronic acid micelles for promoting the skin permeation and deposition of curcumin
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464638/
https://www.ncbi.nlm.nih.gov/pubmed/36105622
http://dx.doi.org/10.2147/IJN.S372711
work_keys_str_mv AT niujiangxiu hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT yuanming hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT zhangzhaowei hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT wangliye hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT fanyanli hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT liuxianghui hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT liuxianming hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT yahuiyuan hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT zhangyansong hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin
AT xuyang hyaluronicacidmicellesforpromotingtheskinpermeationanddepositionofcurcumin