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Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration

Matrix metalloproteinases (MMPs) have been linked to modulating healing during the production of tertiary dentin, as well as the liberation of physiologically active molecules and the control of developmental processes. Although efforts to protect dentin have mostly centered on preventing these prot...

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Detalles Bibliográficos
Autores principales: Agrawal, Paridhi, Nikhade, Pradnya, Chandak, Manoj, Ikhar, Anuja, Bhonde, Rushikesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464706/
https://www.ncbi.nlm.nih.gov/pubmed/36120221
http://dx.doi.org/10.7759/cureus.27946
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author Agrawal, Paridhi
Nikhade, Pradnya
Chandak, Manoj
Ikhar, Anuja
Bhonde, Rushikesh
author_facet Agrawal, Paridhi
Nikhade, Pradnya
Chandak, Manoj
Ikhar, Anuja
Bhonde, Rushikesh
author_sort Agrawal, Paridhi
collection PubMed
description Matrix metalloproteinases (MMPs) have been linked to modulating healing during the production of tertiary dentin, as well as the liberation of physiologically active molecules and the control of developmental processes. Although efforts to protect dentin have mostly centered on preventing these proteases from doing their jobs, their role is actually much more intricate and crucial for dentin healing than anticipated. The role of MMPs as bioactive dentin matrix components involved in dentin production, repair, and regeneration is examined in the current review. The mechanical characteristics of dentin, especially those of reparative and reactionary dentin, and the established functions of MMPs in dentin production are given particular attention. Because they are essential parts of the dentin matrix, MMPs should be regarded as leading applicants for dentin regeneration.
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spelling pubmed-94647062022-09-15 Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration Agrawal, Paridhi Nikhade, Pradnya Chandak, Manoj Ikhar, Anuja Bhonde, Rushikesh Cureus Dentistry Matrix metalloproteinases (MMPs) have been linked to modulating healing during the production of tertiary dentin, as well as the liberation of physiologically active molecules and the control of developmental processes. Although efforts to protect dentin have mostly centered on preventing these proteases from doing their jobs, their role is actually much more intricate and crucial for dentin healing than anticipated. The role of MMPs as bioactive dentin matrix components involved in dentin production, repair, and regeneration is examined in the current review. The mechanical characteristics of dentin, especially those of reparative and reactionary dentin, and the established functions of MMPs in dentin production are given particular attention. Because they are essential parts of the dentin matrix, MMPs should be regarded as leading applicants for dentin regeneration. Cureus 2022-08-12 /pmc/articles/PMC9464706/ /pubmed/36120221 http://dx.doi.org/10.7759/cureus.27946 Text en Copyright © 2022, Agrawal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dentistry
Agrawal, Paridhi
Nikhade, Pradnya
Chandak, Manoj
Ikhar, Anuja
Bhonde, Rushikesh
Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title_full Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title_fullStr Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title_full_unstemmed Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title_short Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration
title_sort dentin matrix metalloproteinases: a futuristic approach toward dentin repair and regeneration
topic Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464706/
https://www.ncbi.nlm.nih.gov/pubmed/36120221
http://dx.doi.org/10.7759/cureus.27946
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