Cargando…
Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain
While current research highlights the role of Nav1. 8 sensory neurons from the peripheral nervous system, the anatomical and physiological characterization of encephalic Nav1.8 neurons remains unknown. Here, we use a Cre/fluorescent reporter mouse driven by the Nav1.8 gene promoter to reveal unexpec...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464809/ https://www.ncbi.nlm.nih.gov/pubmed/36106013 http://dx.doi.org/10.3389/fncel.2022.933874 |
_version_ | 1784787651141828608 |
---|---|
author | Tenza-Ferrer, Helia Collodetti, Mélcar Nicolau, Eduardo de Souza Birbrair, Alexander Magno, Luiz Alexandre Viana Romano-Silva, Marco Aurélio |
author_facet | Tenza-Ferrer, Helia Collodetti, Mélcar Nicolau, Eduardo de Souza Birbrair, Alexander Magno, Luiz Alexandre Viana Romano-Silva, Marco Aurélio |
author_sort | Tenza-Ferrer, Helia |
collection | PubMed |
description | While current research highlights the role of Nav1. 8 sensory neurons from the peripheral nervous system, the anatomical and physiological characterization of encephalic Nav1.8 neurons remains unknown. Here, we use a Cre/fluorescent reporter mouse driven by the Nav1.8 gene promoter to reveal unexpected subpopulations of transiently-expressing Nav1.8 neurons within the limbic circuitry, a key mediator of the emotional component of pain. We observed that Nav1.8 neurons from the bed nuclei of the stria terminalis (BST), amygdala, and the periaqueductal gray (vPAG) are sensitive to noxious stimuli from an experimental model of chronic inflammatory pain. These findings identify a novel role for central Nav1.8 neurons in sensing nociception, which could be researched as a new approach to treating pain disorders. |
format | Online Article Text |
id | pubmed-9464809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94648092022-09-13 Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain Tenza-Ferrer, Helia Collodetti, Mélcar Nicolau, Eduardo de Souza Birbrair, Alexander Magno, Luiz Alexandre Viana Romano-Silva, Marco Aurélio Front Cell Neurosci Cellular Neuroscience While current research highlights the role of Nav1. 8 sensory neurons from the peripheral nervous system, the anatomical and physiological characterization of encephalic Nav1.8 neurons remains unknown. Here, we use a Cre/fluorescent reporter mouse driven by the Nav1.8 gene promoter to reveal unexpected subpopulations of transiently-expressing Nav1.8 neurons within the limbic circuitry, a key mediator of the emotional component of pain. We observed that Nav1.8 neurons from the bed nuclei of the stria terminalis (BST), amygdala, and the periaqueductal gray (vPAG) are sensitive to noxious stimuli from an experimental model of chronic inflammatory pain. These findings identify a novel role for central Nav1.8 neurons in sensing nociception, which could be researched as a new approach to treating pain disorders. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9464809/ /pubmed/36106013 http://dx.doi.org/10.3389/fncel.2022.933874 Text en Copyright © 2022 Tenza-Ferrer, Collodetti, Nicolau, Birbrair, Magno and Romano-Silva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Tenza-Ferrer, Helia Collodetti, Mélcar Nicolau, Eduardo de Souza Birbrair, Alexander Magno, Luiz Alexandre Viana Romano-Silva, Marco Aurélio Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title | Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title_full | Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title_fullStr | Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title_full_unstemmed | Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title_short | Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
title_sort | transiently nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464809/ https://www.ncbi.nlm.nih.gov/pubmed/36106013 http://dx.doi.org/10.3389/fncel.2022.933874 |
work_keys_str_mv | AT tenzaferrerhelia transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain AT collodettimelcar transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain AT nicolaueduardodesouza transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain AT birbrairalexander transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain AT magnoluizalexandreviana transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain AT romanosilvamarcoaurelio transientlynav18expressingneuronsarecapableofsensingnoxiousstimuliinthebrain |