Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer

Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one...

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Detalles Bibliográficos
Autores principales: Chen, Linjiao, Wang, Jie, Liu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464811/
https://www.ncbi.nlm.nih.gov/pubmed/36105363
http://dx.doi.org/10.3389/fcell.2022.999174
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author Chen, Linjiao
Wang, Jie
Liu, Qian
author_facet Chen, Linjiao
Wang, Jie
Liu, Qian
author_sort Chen, Linjiao
collection PubMed
description Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one obstacle for the therapeutic efficacy is due to the development of drug resistance in ovarian cancer patients. Therefore, in this review article, we describe the role of lncRNAs in chemoresistance in ovarian cancer. Moreover, we discuss the molecular mechanism of lncRNAs-involved drug resistance in ovarian cancer. We conclude that lncRNAs could be useful targets to overcome chemoresistance and improve therapeutic outcome in ovarian cancer patients.
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spelling pubmed-94648112022-09-13 Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer Chen, Linjiao Wang, Jie Liu, Qian Front Cell Dev Biol Cell and Developmental Biology Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one obstacle for the therapeutic efficacy is due to the development of drug resistance in ovarian cancer patients. Therefore, in this review article, we describe the role of lncRNAs in chemoresistance in ovarian cancer. Moreover, we discuss the molecular mechanism of lncRNAs-involved drug resistance in ovarian cancer. We conclude that lncRNAs could be useful targets to overcome chemoresistance and improve therapeutic outcome in ovarian cancer patients. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9464811/ /pubmed/36105363 http://dx.doi.org/10.3389/fcell.2022.999174 Text en Copyright © 2022 Chen, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Linjiao
Wang, Jie
Liu, Qian
Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title_full Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title_fullStr Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title_full_unstemmed Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title_short Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer
title_sort long noncoding rnas as therapeutic targets to overcome chemoresistance in ovarian cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464811/
https://www.ncbi.nlm.nih.gov/pubmed/36105363
http://dx.doi.org/10.3389/fcell.2022.999174
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AT wangjie longnoncodingrnasastherapeutictargetstoovercomechemoresistanceinovariancancer
AT liuqian longnoncodingrnasastherapeutictargetstoovercomechemoresistanceinovariancancer

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