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What do we actually know about exosomal microRNAs in kidney diseases?
There are several types of kidney diseases with complex causes. If left untreated, these diseases irreversibly progress to end-stage renal disease. Thus, their early diagnosis and targeted treatment are important. Exosomes—extracellular vesicles released by a variety of cells—are ideal carriers for...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464820/ https://www.ncbi.nlm.nih.gov/pubmed/36105281 http://dx.doi.org/10.3389/fphys.2022.941143 |
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author | Li, Qianyu Zhang, Zhiping Yin, Min Cui, Cancan Zhang, Yucheng Wang, Yali Liu, Feng |
author_facet | Li, Qianyu Zhang, Zhiping Yin, Min Cui, Cancan Zhang, Yucheng Wang, Yali Liu, Feng |
author_sort | Li, Qianyu |
collection | PubMed |
description | There are several types of kidney diseases with complex causes. If left untreated, these diseases irreversibly progress to end-stage renal disease. Thus, their early diagnosis and targeted treatment are important. Exosomes—extracellular vesicles released by a variety of cells—are ideal carriers for DNA, RNA, proteins, and other metabolites owing to their bilayer membranes. Studies have shown that almost all renal cells can secrete exosomes. While research on exosomal microRNAs in the context of renal diseases begun only recently, rapid progress has been achieved. This review summarizes the changes in exosomal microRNA expression in different kidney diseases. Thus, it highlights the diagnostic and prognostic value of these exosomal microRNAs. Further, this review analyzes their roles in the development of different kidney diseases, guiding research on molecular mechanisms and therapeutic strategies. |
format | Online Article Text |
id | pubmed-9464820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94648202022-09-13 What do we actually know about exosomal microRNAs in kidney diseases? Li, Qianyu Zhang, Zhiping Yin, Min Cui, Cancan Zhang, Yucheng Wang, Yali Liu, Feng Front Physiol Physiology There are several types of kidney diseases with complex causes. If left untreated, these diseases irreversibly progress to end-stage renal disease. Thus, their early diagnosis and targeted treatment are important. Exosomes—extracellular vesicles released by a variety of cells—are ideal carriers for DNA, RNA, proteins, and other metabolites owing to their bilayer membranes. Studies have shown that almost all renal cells can secrete exosomes. While research on exosomal microRNAs in the context of renal diseases begun only recently, rapid progress has been achieved. This review summarizes the changes in exosomal microRNA expression in different kidney diseases. Thus, it highlights the diagnostic and prognostic value of these exosomal microRNAs. Further, this review analyzes their roles in the development of different kidney diseases, guiding research on molecular mechanisms and therapeutic strategies. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9464820/ /pubmed/36105281 http://dx.doi.org/10.3389/fphys.2022.941143 Text en Copyright © 2022 Li, Zhang, Yin, Cui, Zhang, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Li, Qianyu Zhang, Zhiping Yin, Min Cui, Cancan Zhang, Yucheng Wang, Yali Liu, Feng What do we actually know about exosomal microRNAs in kidney diseases? |
title | What do we actually know about exosomal microRNAs in kidney diseases? |
title_full | What do we actually know about exosomal microRNAs in kidney diseases? |
title_fullStr | What do we actually know about exosomal microRNAs in kidney diseases? |
title_full_unstemmed | What do we actually know about exosomal microRNAs in kidney diseases? |
title_short | What do we actually know about exosomal microRNAs in kidney diseases? |
title_sort | what do we actually know about exosomal micrornas in kidney diseases? |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464820/ https://www.ncbi.nlm.nih.gov/pubmed/36105281 http://dx.doi.org/10.3389/fphys.2022.941143 |
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