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Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients?
OBJECTIVE: We aim to investigate whether the use of dipeptidyl peptidase inhibitors (DPP-4i) affects the severity of disease, hospital mortality, and 3-month post-discharge mortality in type 2 diabetes mellitus (T2DM) individuals with coronavirus disease 2019 (COVID-19) infection. METHODS: The study...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464847/ https://www.ncbi.nlm.nih.gov/pubmed/36199855 http://dx.doi.org/10.14744/nci.2022.34341 |
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author | Erol, Rumeysa Selvinaz Sen, Esra Cil Ozturk, Feyza Yener Sarac, Zeynep Kokoglu, Gizem Leyla Canat, Muhammed Masum Yildiz, Duygu Aytekin, Yunus Emre Sevgi, Dilek Yildiz Altuntas, Yuksel |
author_facet | Erol, Rumeysa Selvinaz Sen, Esra Cil Ozturk, Feyza Yener Sarac, Zeynep Kokoglu, Gizem Leyla Canat, Muhammed Masum Yildiz, Duygu Aytekin, Yunus Emre Sevgi, Dilek Yildiz Altuntas, Yuksel |
author_sort | Erol, Rumeysa Selvinaz |
collection | PubMed |
description | OBJECTIVE: We aim to investigate whether the use of dipeptidyl peptidase inhibitors (DPP-4i) affects the severity of disease, hospital mortality, and 3-month post-discharge mortality in type 2 diabetes mellitus (T2DM) individuals with coronavirus disease 2019 (COVID-19) infection. METHODS: The study included 217 patients with type 2 diabetes hospitalized due to COVID-19 between March and October 2020. The patients included in the study were divided into two groups those using DPP-4i and those not using DPP-4i. Demographic characteristics, laboratory parameters, accompanying risk factors, concomitant comorbidities, hospital mortality, clinical course, and 3-month post-discharge mortality were compared between the patients who used DPP-4i and those who did not use. RESULTS: The duration of hospitalization was 10.96±9.16 days in the group using DPP-4i, 12.22±9.1 days in the group not using DPP-4i, and when both groups were evaluated together, it was determined as 11.91±9.11 days. The hospitalization periods were similar between DPP-4i users and non-DPP-4i users (p=0.384). The need for mechanical ventilation (p=0.478 OR 0.710 95% confidence interval [CI], 0.274–1.836) and high-flow nasal cannula (p=0.457, OR: 0.331, 95% CI: 0.41–2.67) were similar between DPP-4i users and non-users. It was determined that the mortality (p=0.208, OR: 0.409, 95% CI: 0.117–1.429) and 3-month post-discharge mortality (p=0.383) were similar in the group using DPP-4i and those not using DPP-4i. CONCLUSION: This study demonstrated that the use of DPP-4i by patients with T2DM in catching COVID-19 does not affect the mortality due to COVID-19, the severity of COVID-19 disease, and 3-month post-discharge mortality. |
format | Online Article Text |
id | pubmed-9464847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-94648472022-10-04 Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? Erol, Rumeysa Selvinaz Sen, Esra Cil Ozturk, Feyza Yener Sarac, Zeynep Kokoglu, Gizem Leyla Canat, Muhammed Masum Yildiz, Duygu Aytekin, Yunus Emre Sevgi, Dilek Yildiz Altuntas, Yuksel North Clin Istanb Original Article OBJECTIVE: We aim to investigate whether the use of dipeptidyl peptidase inhibitors (DPP-4i) affects the severity of disease, hospital mortality, and 3-month post-discharge mortality in type 2 diabetes mellitus (T2DM) individuals with coronavirus disease 2019 (COVID-19) infection. METHODS: The study included 217 patients with type 2 diabetes hospitalized due to COVID-19 between March and October 2020. The patients included in the study were divided into two groups those using DPP-4i and those not using DPP-4i. Demographic characteristics, laboratory parameters, accompanying risk factors, concomitant comorbidities, hospital mortality, clinical course, and 3-month post-discharge mortality were compared between the patients who used DPP-4i and those who did not use. RESULTS: The duration of hospitalization was 10.96±9.16 days in the group using DPP-4i, 12.22±9.1 days in the group not using DPP-4i, and when both groups were evaluated together, it was determined as 11.91±9.11 days. The hospitalization periods were similar between DPP-4i users and non-DPP-4i users (p=0.384). The need for mechanical ventilation (p=0.478 OR 0.710 95% confidence interval [CI], 0.274–1.836) and high-flow nasal cannula (p=0.457, OR: 0.331, 95% CI: 0.41–2.67) were similar between DPP-4i users and non-users. It was determined that the mortality (p=0.208, OR: 0.409, 95% CI: 0.117–1.429) and 3-month post-discharge mortality (p=0.383) were similar in the group using DPP-4i and those not using DPP-4i. CONCLUSION: This study demonstrated that the use of DPP-4i by patients with T2DM in catching COVID-19 does not affect the mortality due to COVID-19, the severity of COVID-19 disease, and 3-month post-discharge mortality. Kare Publishing 2022-07-05 /pmc/articles/PMC9464847/ /pubmed/36199855 http://dx.doi.org/10.14744/nci.2022.34341 Text en © Copyright 2022 by Istanbul Provincial Directorate of Health https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Erol, Rumeysa Selvinaz Sen, Esra Cil Ozturk, Feyza Yener Sarac, Zeynep Kokoglu, Gizem Leyla Canat, Muhammed Masum Yildiz, Duygu Aytekin, Yunus Emre Sevgi, Dilek Yildiz Altuntas, Yuksel Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title | Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title_full | Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title_fullStr | Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title_full_unstemmed | Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title_short | Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients? |
title_sort | does dpp-4 inhibitor treatment affect the clinical outcomes of covid-19 in type 2 diabetes mellitus patients? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464847/ https://www.ncbi.nlm.nih.gov/pubmed/36199855 http://dx.doi.org/10.14744/nci.2022.34341 |
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