Serum apelin levels and cardiovascular diseases

Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the most potent stimulants of ventricular contrac...

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Detalles Bibliográficos
Autores principales: Askin, Lutfu, Askin, Husna Sengul, Tanrıverdi, Okan, Ozyildiz, Ali Gokhan, Duman, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464848/
https://www.ncbi.nlm.nih.gov/pubmed/36199867
http://dx.doi.org/10.14744/nci.2021.33427
Descripción
Sumario:Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the most potent stimulants of ventricular contraction. Apelin may be a valuable therapeutic for both blood pressure regulation and myocardial performance. More information is needed for the CV pathophysiology of apelin. We will discuss the importance of apelin level in CV diseases in this review.

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