The role of tumor-associated macrophages in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Yiwen, Song, Xiao, Fan, Siyu, Deng, Runzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464857/
https://www.ncbi.nlm.nih.gov/pubmed/36105288
http://dx.doi.org/10.3389/fphys.2022.959747
_version_ 1784787662895316992
author Xue, Yiwen
Song, Xiao
Fan, Siyu
Deng, Runzhi
author_facet Xue, Yiwen
Song, Xiao
Fan, Siyu
Deng, Runzhi
author_sort Xue, Yiwen
collection PubMed
description Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.
format Online
Article
Text
id pubmed-9464857
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94648572022-09-13 The role of tumor-associated macrophages in oral squamous cell carcinoma Xue, Yiwen Song, Xiao Fan, Siyu Deng, Runzhi Front Physiol Physiology Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9464857/ /pubmed/36105288 http://dx.doi.org/10.3389/fphys.2022.959747 Text en Copyright © 2022 Xue, Song, Fan and Deng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xue, Yiwen
Song, Xiao
Fan, Siyu
Deng, Runzhi
The role of tumor-associated macrophages in oral squamous cell carcinoma
title The role of tumor-associated macrophages in oral squamous cell carcinoma
title_full The role of tumor-associated macrophages in oral squamous cell carcinoma
title_fullStr The role of tumor-associated macrophages in oral squamous cell carcinoma
title_full_unstemmed The role of tumor-associated macrophages in oral squamous cell carcinoma
title_short The role of tumor-associated macrophages in oral squamous cell carcinoma
title_sort role of tumor-associated macrophages in oral squamous cell carcinoma
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464857/
https://www.ncbi.nlm.nih.gov/pubmed/36105288
http://dx.doi.org/10.3389/fphys.2022.959747
work_keys_str_mv AT xueyiwen theroleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT songxiao theroleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT fansiyu theroleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT dengrunzhi theroleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT xueyiwen roleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT songxiao roleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT fansiyu roleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma
AT dengrunzhi roleoftumorassociatedmacrophagesinoralsquamouscellcarcinoma

Ejemplares similares