Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes

Live bacterial therapeutics (LBTs) could reverse diseases by engrafting in the gut and providing persistent beneficial functions in the host. However, attempts to functionally manipulate the gut microbiome of conventionally raised (CR) hosts have been unsuccessful because engineered microbial organi...

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Detalles Bibliográficos
Autores principales: Russell, Baylee J., Brown, Steven D., Siguenza, Nicole, Mai, Irene, Saran, Anand R., Lingaraju, Amulya, Maissy, Erica S., Machado, Ana C. Dantas, Pinto, Antonio F.M., Sanchez, Concepcion, Rossitto, Leigh-Ana, Miyamoto, Yukiko, Richter, R. Alexander, Ho, Samuel B., Eckmann, Lars, Hasty, Jeff, Gonzalez, David J., Saghatelian, Alan, Knight, Rob, Zarrinpar, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464905/
https://www.ncbi.nlm.nih.gov/pubmed/35931082
http://dx.doi.org/10.1016/j.cell.2022.06.050

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