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Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment

Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demograph...

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Autores principales: Chen, Li-Da, Hu, Lan, Song, Yang, Huang, Ya-Ping, Yang, Si-Jiu, Yang, Juan, Zhang, Xiao-bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464930/
http://dx.doi.org/10.1177/1721727X221126117
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author Chen, Li-Da
Hu, Lan
Song, Yang
Huang, Ya-Ping
Yang, Si-Jiu
Yang, Juan
Zhang, Xiao-bin
author_facet Chen, Li-Da
Hu, Lan
Song, Yang
Huang, Ya-Ping
Yang, Si-Jiu
Yang, Juan
Zhang, Xiao-bin
author_sort Chen, Li-Da
collection PubMed
description Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demographic characteristics, underlying diseases, signs, symptoms, and laboratory data of 100 COVID-19 patients were collected and analyzed in this retrospective study. Patients were divided into three groups: mild, moderate, and severe to critical group. Kidney injury was evaluated by markers including estimated glomerular filtration rate (eGFR), serum creatinine, blood urea nitrogen, and cystatin C. Results: A total of 100 patients with 12 mild, 63 moderate, and 25 severe to critical COVID-19 were included in this study. The kidney injury markers including eGFR, serum creatinine, blood urea nitrogen, and cystatin C all worsened significantly with an increase in disease severity. The correlation test showed that cytokines IL-2R, IL-6, IL-8, and tumor necrosis factor (TNF)-α were statistically correlated with eGFR and cystatin C. In multivariate analysis, log IL-6 (β = −0.331, p = .001 for eGFR and β = 0.405, p < .001 for cystatin C) and log TNF-α (β = −0.316, p = .001 for eGFR and β = 0.534, p < .001 for cystatin C) were found to be the major independent predictors of kidney injury. Conclusion: Serum IL-6 and TNF-α levels were the major independent predictors of kidney injury in COVID-19.
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spelling pubmed-94649302022-09-13 Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment Chen, Li-Da Hu, Lan Song, Yang Huang, Ya-Ping Yang, Si-Jiu Yang, Juan Zhang, Xiao-bin European Journal of Inflammation Original Research Article Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demographic characteristics, underlying diseases, signs, symptoms, and laboratory data of 100 COVID-19 patients were collected and analyzed in this retrospective study. Patients were divided into three groups: mild, moderate, and severe to critical group. Kidney injury was evaluated by markers including estimated glomerular filtration rate (eGFR), serum creatinine, blood urea nitrogen, and cystatin C. Results: A total of 100 patients with 12 mild, 63 moderate, and 25 severe to critical COVID-19 were included in this study. The kidney injury markers including eGFR, serum creatinine, blood urea nitrogen, and cystatin C all worsened significantly with an increase in disease severity. The correlation test showed that cytokines IL-2R, IL-6, IL-8, and tumor necrosis factor (TNF)-α were statistically correlated with eGFR and cystatin C. In multivariate analysis, log IL-6 (β = −0.331, p = .001 for eGFR and β = 0.405, p < .001 for cystatin C) and log TNF-α (β = −0.316, p = .001 for eGFR and β = 0.534, p < .001 for cystatin C) were found to be the major independent predictors of kidney injury. Conclusion: Serum IL-6 and TNF-α levels were the major independent predictors of kidney injury in COVID-19. SAGE Publications 2022-09-09 /pmc/articles/PMC9464930/ http://dx.doi.org/10.1177/1721727X221126117 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Chen, Li-Da
Hu, Lan
Song, Yang
Huang, Ya-Ping
Yang, Si-Jiu
Yang, Juan
Zhang, Xiao-bin
Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title_full Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title_fullStr Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title_full_unstemmed Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title_short Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
title_sort role of serum il-6 and tnf-α in coronavirus disease 2019 (covid-19) associated renal impairment
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464930/
http://dx.doi.org/10.1177/1721727X221126117
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