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Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment
Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demograph...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464930/ http://dx.doi.org/10.1177/1721727X221126117 |
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author | Chen, Li-Da Hu, Lan Song, Yang Huang, Ya-Ping Yang, Si-Jiu Yang, Juan Zhang, Xiao-bin |
author_facet | Chen, Li-Da Hu, Lan Song, Yang Huang, Ya-Ping Yang, Si-Jiu Yang, Juan Zhang, Xiao-bin |
author_sort | Chen, Li-Da |
collection | PubMed |
description | Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demographic characteristics, underlying diseases, signs, symptoms, and laboratory data of 100 COVID-19 patients were collected and analyzed in this retrospective study. Patients were divided into three groups: mild, moderate, and severe to critical group. Kidney injury was evaluated by markers including estimated glomerular filtration rate (eGFR), serum creatinine, blood urea nitrogen, and cystatin C. Results: A total of 100 patients with 12 mild, 63 moderate, and 25 severe to critical COVID-19 were included in this study. The kidney injury markers including eGFR, serum creatinine, blood urea nitrogen, and cystatin C all worsened significantly with an increase in disease severity. The correlation test showed that cytokines IL-2R, IL-6, IL-8, and tumor necrosis factor (TNF)-α were statistically correlated with eGFR and cystatin C. In multivariate analysis, log IL-6 (β = −0.331, p = .001 for eGFR and β = 0.405, p < .001 for cystatin C) and log TNF-α (β = −0.316, p = .001 for eGFR and β = 0.534, p < .001 for cystatin C) were found to be the major independent predictors of kidney injury. Conclusion: Serum IL-6 and TNF-α levels were the major independent predictors of kidney injury in COVID-19. |
format | Online Article Text |
id | pubmed-9464930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-94649302022-09-13 Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment Chen, Li-Da Hu, Lan Song, Yang Huang, Ya-Ping Yang, Si-Jiu Yang, Juan Zhang, Xiao-bin European Journal of Inflammation Original Research Article Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demographic characteristics, underlying diseases, signs, symptoms, and laboratory data of 100 COVID-19 patients were collected and analyzed in this retrospective study. Patients were divided into three groups: mild, moderate, and severe to critical group. Kidney injury was evaluated by markers including estimated glomerular filtration rate (eGFR), serum creatinine, blood urea nitrogen, and cystatin C. Results: A total of 100 patients with 12 mild, 63 moderate, and 25 severe to critical COVID-19 were included in this study. The kidney injury markers including eGFR, serum creatinine, blood urea nitrogen, and cystatin C all worsened significantly with an increase in disease severity. The correlation test showed that cytokines IL-2R, IL-6, IL-8, and tumor necrosis factor (TNF)-α were statistically correlated with eGFR and cystatin C. In multivariate analysis, log IL-6 (β = −0.331, p = .001 for eGFR and β = 0.405, p < .001 for cystatin C) and log TNF-α (β = −0.316, p = .001 for eGFR and β = 0.534, p < .001 for cystatin C) were found to be the major independent predictors of kidney injury. Conclusion: Serum IL-6 and TNF-α levels were the major independent predictors of kidney injury in COVID-19. SAGE Publications 2022-09-09 /pmc/articles/PMC9464930/ http://dx.doi.org/10.1177/1721727X221126117 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Chen, Li-Da Hu, Lan Song, Yang Huang, Ya-Ping Yang, Si-Jiu Yang, Juan Zhang, Xiao-bin Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title | Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title_full | Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title_fullStr | Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title_full_unstemmed | Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title_short | Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment |
title_sort | role of serum il-6 and tnf-α in coronavirus disease 2019 (covid-19) associated renal impairment |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464930/ http://dx.doi.org/10.1177/1721727X221126117 |
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