The ethical case for placebo control in HIV-cure-related studies with ART interruption

Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.

Detalles Bibliográficos
Autores principales: Magalhaes, Monica, Kuritzkes, Daniel R., Eyal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464947/
https://www.ncbi.nlm.nih.gov/pubmed/36106155
http://dx.doi.org/10.1016/j.jve.2022.100084
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author Magalhaes, Monica
Kuritzkes, Daniel R.
Eyal, Nir
author_facet Magalhaes, Monica
Kuritzkes, Daniel R.
Eyal, Nir
author_sort Magalhaes, Monica
collection PubMed
description Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.
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spelling pubmed-94649472022-09-13 The ethical case for placebo control in HIV-cure-related studies with ART interruption Magalhaes, Monica Kuritzkes, Daniel R. Eyal, Nir J Virus Erad Original Research Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined. Elsevier 2022-08-28 /pmc/articles/PMC9464947/ /pubmed/36106155 http://dx.doi.org/10.1016/j.jve.2022.100084 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Magalhaes, Monica
Kuritzkes, Daniel R.
Eyal, Nir
The ethical case for placebo control in HIV-cure-related studies with ART interruption
title The ethical case for placebo control in HIV-cure-related studies with ART interruption
title_full The ethical case for placebo control in HIV-cure-related studies with ART interruption
title_fullStr The ethical case for placebo control in HIV-cure-related studies with ART interruption
title_full_unstemmed The ethical case for placebo control in HIV-cure-related studies with ART interruption
title_short The ethical case for placebo control in HIV-cure-related studies with ART interruption
title_sort ethical case for placebo control in hiv-cure-related studies with art interruption
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464947/
https://www.ncbi.nlm.nih.gov/pubmed/36106155
http://dx.doi.org/10.1016/j.jve.2022.100084
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