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RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

OBJECTIVE: Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β-cell loss and hyperglycemia in non-obese diabetic mice and human T1D, the molecular mechanisms of β-cell TNF receptor signali...

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Detalles Bibliográficos
Autores principales:	Contreras, Christopher J., Mukherjee, Noyonika, Branco, Renato C.S., Lin, Li, Hogan, Meghan F., Cai, Erica P., Oberst, Andrew A., Kahn, Steven E., Templin, Andrew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464965/ https://www.ncbi.nlm.nih.gov/pubmed/36030035 http://dx.doi.org/10.1016/j.molmet.2022.101582

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