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Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cogniti...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464997/ https://www.ncbi.nlm.nih.gov/pubmed/36110432 http://dx.doi.org/10.1002/dad2.12351 |
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author | Cody, Karly A. Koscik, Rebecca L. Erickson, Claire M. Berman, Sara E. Jonaitis, Erin M. Williams, Victoria J. Mueller, Kimberly D. Christian, Bradley T. Chin, Nathanial A. Clark, Lindsay R. Betthauser, Tobey J. Johnson, Sterling C. |
author_facet | Cody, Karly A. Koscik, Rebecca L. Erickson, Claire M. Berman, Sara E. Jonaitis, Erin M. Williams, Victoria J. Mueller, Kimberly D. Christian, Bradley T. Chin, Nathanial A. Clark, Lindsay R. Betthauser, Tobey J. Johnson, Sterling C. |
author_sort | Cody, Karly A. |
collection | PubMed |
description | INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cognitively unimpaired, late middle‐aged participants (N = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle‐based dementia risk score, on AD‐related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. RESULTS: Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ‐related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. DISCUSSION: In WRAP, late‐midlife LIBRA scores were related to overall cognitive performance, but not AD‐related cognitive decline or Aβ accumulation in the preclinical timeframe. HIGHLIGHTS: The Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late‐midlife. LIBRA did not moderate apolipoprotein E ε4 or amyloid‐related cognitive decline. LIBRA was not associated with the onset or accumulation of amyloid plaques. |
format | Online Article Text |
id | pubmed-9464997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94649972022-09-14 Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention Cody, Karly A. Koscik, Rebecca L. Erickson, Claire M. Berman, Sara E. Jonaitis, Erin M. Williams, Victoria J. Mueller, Kimberly D. Christian, Bradley T. Chin, Nathanial A. Clark, Lindsay R. Betthauser, Tobey J. Johnson, Sterling C. Alzheimers Dement (Amst) Disease Prevention INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cognitively unimpaired, late middle‐aged participants (N = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle‐based dementia risk score, on AD‐related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. RESULTS: Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ‐related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. DISCUSSION: In WRAP, late‐midlife LIBRA scores were related to overall cognitive performance, but not AD‐related cognitive decline or Aβ accumulation in the preclinical timeframe. HIGHLIGHTS: The Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late‐midlife. LIBRA did not moderate apolipoprotein E ε4 or amyloid‐related cognitive decline. LIBRA was not associated with the onset or accumulation of amyloid plaques. John Wiley and Sons Inc. 2022-09-11 /pmc/articles/PMC9464997/ /pubmed/36110432 http://dx.doi.org/10.1002/dad2.12351 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Disease Prevention Cody, Karly A. Koscik, Rebecca L. Erickson, Claire M. Berman, Sara E. Jonaitis, Erin M. Williams, Victoria J. Mueller, Kimberly D. Christian, Bradley T. Chin, Nathanial A. Clark, Lindsay R. Betthauser, Tobey J. Johnson, Sterling C. Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title | Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title_full | Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title_fullStr | Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title_full_unstemmed | Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title_short | Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention |
title_sort | associations of the lifestyle for brain health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: findings from the wisconsin registry for alzheimer's prevention |
topic | Disease Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464997/ https://www.ncbi.nlm.nih.gov/pubmed/36110432 http://dx.doi.org/10.1002/dad2.12351 |
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