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Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention

INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cogniti...

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Autores principales: Cody, Karly A., Koscik, Rebecca L., Erickson, Claire M., Berman, Sara E., Jonaitis, Erin M., Williams, Victoria J., Mueller, Kimberly D., Christian, Bradley T., Chin, Nathanial A., Clark, Lindsay R., Betthauser, Tobey J., Johnson, Sterling C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464997/
https://www.ncbi.nlm.nih.gov/pubmed/36110432
http://dx.doi.org/10.1002/dad2.12351
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author Cody, Karly A.
Koscik, Rebecca L.
Erickson, Claire M.
Berman, Sara E.
Jonaitis, Erin M.
Williams, Victoria J.
Mueller, Kimberly D.
Christian, Bradley T.
Chin, Nathanial A.
Clark, Lindsay R.
Betthauser, Tobey J.
Johnson, Sterling C.
author_facet Cody, Karly A.
Koscik, Rebecca L.
Erickson, Claire M.
Berman, Sara E.
Jonaitis, Erin M.
Williams, Victoria J.
Mueller, Kimberly D.
Christian, Bradley T.
Chin, Nathanial A.
Clark, Lindsay R.
Betthauser, Tobey J.
Johnson, Sterling C.
author_sort Cody, Karly A.
collection PubMed
description INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cognitively unimpaired, late middle‐aged participants (N = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle‐based dementia risk score, on AD‐related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. RESULTS: Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ‐related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. DISCUSSION: In WRAP, late‐midlife LIBRA scores were related to overall cognitive performance, but not AD‐related cognitive decline or Aβ accumulation in the preclinical timeframe. HIGHLIGHTS: The Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late‐midlife. LIBRA did not moderate apolipoprotein E ε4 or amyloid‐related cognitive decline. LIBRA was not associated with the onset or accumulation of amyloid plaques.
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spelling pubmed-94649972022-09-14 Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention Cody, Karly A. Koscik, Rebecca L. Erickson, Claire M. Berman, Sara E. Jonaitis, Erin M. Williams, Victoria J. Mueller, Kimberly D. Christian, Bradley T. Chin, Nathanial A. Clark, Lindsay R. Betthauser, Tobey J. Johnson, Sterling C. Alzheimers Dement (Amst) Disease Prevention INTRODUCTION: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. METHODS: In initially cognitively unimpaired, late middle‐aged participants (N = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle‐based dementia risk score, on AD‐related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. RESULTS: Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ‐related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. DISCUSSION: In WRAP, late‐midlife LIBRA scores were related to overall cognitive performance, but not AD‐related cognitive decline or Aβ accumulation in the preclinical timeframe. HIGHLIGHTS: The Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late‐midlife. LIBRA did not moderate apolipoprotein E ε4 or amyloid‐related cognitive decline. LIBRA was not associated with the onset or accumulation of amyloid plaques. John Wiley and Sons Inc. 2022-09-11 /pmc/articles/PMC9464997/ /pubmed/36110432 http://dx.doi.org/10.1002/dad2.12351 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Disease Prevention
Cody, Karly A.
Koscik, Rebecca L.
Erickson, Claire M.
Berman, Sara E.
Jonaitis, Erin M.
Williams, Victoria J.
Mueller, Kimberly D.
Christian, Bradley T.
Chin, Nathanial A.
Clark, Lindsay R.
Betthauser, Tobey J.
Johnson, Sterling C.
Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title_full Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title_fullStr Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title_full_unstemmed Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title_short Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
title_sort associations of the lifestyle for brain health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: findings from the wisconsin registry for alzheimer's prevention
topic Disease Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464997/
https://www.ncbi.nlm.nih.gov/pubmed/36110432
http://dx.doi.org/10.1002/dad2.12351
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