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Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS/p38 MAPK/DGAT1 pathway and inhibiting M2 macrophage polarization

PURPOSE: Bile acids are steroid synthesized in liver, which are essential for fat emulsification, cholesterol excretion and gut microbial homeostasis. However, the role of bile acids in leukemia progression remains unclear. We aim at exploring the effects and mechanisms of chenodeoxycholic acid (CDC...

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Detalles Bibliográficos
Autores principales:	Liu, Jinting, Wei, Yihong, Jia, Wenbo, Can, Can, Wang, Ruiqing, Yang, Xinyu, Gu, Chaoyang, Liu, Fabao, Ji, Chunyan, Ma, Daoxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465103/ https://www.ncbi.nlm.nih.gov/pubmed/36084349 http://dx.doi.org/10.1016/j.redox.2022.102452

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