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Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma

N(7)-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, a comprehensive analysis was executed to explore prognostic roles and associations with the immune status of the m7G-related lncRNA (m7G-RNAs) in colon adenocarcinoma (COAD). Identification of...

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Autores principales: Ma, Xiaomei, Yang, Baoshun, Yang, Yuan, Wu, Guozhi, Ma, Xiaoli, Yu, Xiao, Li, Yingwen, Wang, Yuping, Guo, Qinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465161/
https://www.ncbi.nlm.nih.gov/pubmed/36105111
http://dx.doi.org/10.3389/fgene.2022.946845
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author Ma, Xiaomei
Yang, Baoshun
Yang, Yuan
Wu, Guozhi
Ma, Xiaoli
Yu, Xiao
Li, Yingwen
Wang, Yuping
Guo, Qinghong
author_facet Ma, Xiaomei
Yang, Baoshun
Yang, Yuan
Wu, Guozhi
Ma, Xiaoli
Yu, Xiao
Li, Yingwen
Wang, Yuping
Guo, Qinghong
author_sort Ma, Xiaomei
collection PubMed
description N(7)-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, a comprehensive analysis was executed to explore prognostic roles and associations with the immune status of the m7G-related lncRNA (m7G-RNAs) in colon adenocarcinoma (COAD). Identification of m7G-RNAs was achieved via Pearson’s correlation analysis of lncRNAs in the TCGA-COAD dataset and m7G regulators. A prognostic signature was developed via LASSO analyses. ESTIMATE, CIBERSORT, and ssGSEA algorithms were utilized to assess immune infiltration between different risk groups. Survival analysis suggested the high-risk group possesses poor outcomes compared with the low-risk group. According to the ROC curves, the m7G-RNAs signature exhibited a reliable capability of prediction (AUCs at 1, 3, and 5 years were 0.770, 0.766, and 0.849, respectively). Multivariate hazard analysis proved that the signature was an independent predictive indicator for OS. Moreover, the risk score was related to infiltration levels of naïve B cells, CD4(+) memory T cells, and resting NK cells. The result revealed the prognostic value of m7G modification in COAD and provided a novel perspective on personalized immunotherapy strategies.
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spelling pubmed-94651612022-09-13 Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma Ma, Xiaomei Yang, Baoshun Yang, Yuan Wu, Guozhi Ma, Xiaoli Yu, Xiao Li, Yingwen Wang, Yuping Guo, Qinghong Front Genet Genetics N(7)-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, a comprehensive analysis was executed to explore prognostic roles and associations with the immune status of the m7G-related lncRNA (m7G-RNAs) in colon adenocarcinoma (COAD). Identification of m7G-RNAs was achieved via Pearson’s correlation analysis of lncRNAs in the TCGA-COAD dataset and m7G regulators. A prognostic signature was developed via LASSO analyses. ESTIMATE, CIBERSORT, and ssGSEA algorithms were utilized to assess immune infiltration between different risk groups. Survival analysis suggested the high-risk group possesses poor outcomes compared with the low-risk group. According to the ROC curves, the m7G-RNAs signature exhibited a reliable capability of prediction (AUCs at 1, 3, and 5 years were 0.770, 0.766, and 0.849, respectively). Multivariate hazard analysis proved that the signature was an independent predictive indicator for OS. Moreover, the risk score was related to infiltration levels of naïve B cells, CD4(+) memory T cells, and resting NK cells. The result revealed the prognostic value of m7G modification in COAD and provided a novel perspective on personalized immunotherapy strategies. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465161/ /pubmed/36105111 http://dx.doi.org/10.3389/fgene.2022.946845 Text en Copyright © 2022 Ma, Yang, Yang, Wu, Ma, Yu, Li, Wang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ma, Xiaomei
Yang, Baoshun
Yang, Yuan
Wu, Guozhi
Ma, Xiaoli
Yu, Xiao
Li, Yingwen
Wang, Yuping
Guo, Qinghong
Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title_full Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title_fullStr Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title_full_unstemmed Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title_short Identification of N(7)-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma
title_sort identification of n(7)-methylguanosine-related incrna signature as a potential predictive biomarker for colon adenocarcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465161/
https://www.ncbi.nlm.nih.gov/pubmed/36105111
http://dx.doi.org/10.3389/fgene.2022.946845
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