Case Report: Respiratory paralysis associated with polymyxin B therapy

Polymyxin B (PMB) and colistin are bactericidal polypeptide antibiotics discovered in 1947 and 1949 for the treatment of gram-negative bacterial infections. Polymyxin was used clinically in the 1950s, but it was gradually replaced by other antibiotics in the 1980s because of its high nephrotoxicity...

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Autores principales: Ning, Yachan, Chu, Yanqi, Wu, You, Huang, Ying, Wang, Chunmei, Jiang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465242/
https://www.ncbi.nlm.nih.gov/pubmed/36105193
http://dx.doi.org/10.3389/fphar.2022.963140
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author Ning, Yachan
Chu, Yanqi
Wu, You
Huang, Ying
Wang, Chunmei
Jiang, Li
author_facet Ning, Yachan
Chu, Yanqi
Wu, You
Huang, Ying
Wang, Chunmei
Jiang, Li
author_sort Ning, Yachan
collection PubMed
description Polymyxin B (PMB) and colistin are bactericidal polypeptide antibiotics discovered in 1947 and 1949 for the treatment of gram-negative bacterial infections. Polymyxin was used clinically in the 1950s, but it was gradually replaced by other antibiotics in the 1980s because of its high nephrotoxicity and neurotoxicity. In recent years, the increase of multidrug-resistant negative bacteria has led to the resurgence of polymyxin use. However, its side effects are not clear. Respiratory paralysis caused by PMB-related neuromuscular blockade is a rare but potentially fatal effect. We report a case of respiratory paralysis probably caused by polymyxin B infusion.
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spelling pubmed-94652422022-09-13 Case Report: Respiratory paralysis associated with polymyxin B therapy Ning, Yachan Chu, Yanqi Wu, You Huang, Ying Wang, Chunmei Jiang, Li Front Pharmacol Pharmacology Polymyxin B (PMB) and colistin are bactericidal polypeptide antibiotics discovered in 1947 and 1949 for the treatment of gram-negative bacterial infections. Polymyxin was used clinically in the 1950s, but it was gradually replaced by other antibiotics in the 1980s because of its high nephrotoxicity and neurotoxicity. In recent years, the increase of multidrug-resistant negative bacteria has led to the resurgence of polymyxin use. However, its side effects are not clear. Respiratory paralysis caused by PMB-related neuromuscular blockade is a rare but potentially fatal effect. We report a case of respiratory paralysis probably caused by polymyxin B infusion. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465242/ /pubmed/36105193 http://dx.doi.org/10.3389/fphar.2022.963140 Text en Copyright © 2022 Ning, Chu, Wu, Huang, Wang and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ning, Yachan
Chu, Yanqi
Wu, You
Huang, Ying
Wang, Chunmei
Jiang, Li
Case Report: Respiratory paralysis associated with polymyxin B therapy
title Case Report: Respiratory paralysis associated with polymyxin B therapy
title_full Case Report: Respiratory paralysis associated with polymyxin B therapy
title_fullStr Case Report: Respiratory paralysis associated with polymyxin B therapy
title_full_unstemmed Case Report: Respiratory paralysis associated with polymyxin B therapy
title_short Case Report: Respiratory paralysis associated with polymyxin B therapy
title_sort case report: respiratory paralysis associated with polymyxin b therapy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465242/
https://www.ncbi.nlm.nih.gov/pubmed/36105193
http://dx.doi.org/10.3389/fphar.2022.963140
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