The roles and applications of neural stem cells in spinal cord injury repair

Spinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and...

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Autores principales: Guo, Wen, Zhang, Xindan, Zhai, Jiliang, Xue, Jiajia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465243/
https://www.ncbi.nlm.nih.gov/pubmed/36105599
http://dx.doi.org/10.3389/fbioe.2022.966866
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author Guo, Wen
Zhang, Xindan
Zhai, Jiliang
Xue, Jiajia
author_facet Guo, Wen
Zhang, Xindan
Zhai, Jiliang
Xue, Jiajia
author_sort Guo, Wen
collection PubMed
description Spinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and neuroglial lineages. This feature makes NSCs suitable candidates for regenerating injured spinal cords. Many studies have revealed the therapeutic potential of NSCs. In this review, we discuss from an integrated view how NSCs can help SCI repair. We will discuss the sources and therapeutic potential of NSCs, as well as representative pre-clinical studies and clinical trials of NSC-based therapies for SCI repair.
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spelling pubmed-94652432022-09-13 The roles and applications of neural stem cells in spinal cord injury repair Guo, Wen Zhang, Xindan Zhai, Jiliang Xue, Jiajia Front Bioeng Biotechnol Bioengineering and Biotechnology Spinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and neuroglial lineages. This feature makes NSCs suitable candidates for regenerating injured spinal cords. Many studies have revealed the therapeutic potential of NSCs. In this review, we discuss from an integrated view how NSCs can help SCI repair. We will discuss the sources and therapeutic potential of NSCs, as well as representative pre-clinical studies and clinical trials of NSC-based therapies for SCI repair. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465243/ /pubmed/36105599 http://dx.doi.org/10.3389/fbioe.2022.966866 Text en Copyright © 2022 Guo, Zhang, Zhai and Xue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Guo, Wen
Zhang, Xindan
Zhai, Jiliang
Xue, Jiajia
The roles and applications of neural stem cells in spinal cord injury repair
title The roles and applications of neural stem cells in spinal cord injury repair
title_full The roles and applications of neural stem cells in spinal cord injury repair
title_fullStr The roles and applications of neural stem cells in spinal cord injury repair
title_full_unstemmed The roles and applications of neural stem cells in spinal cord injury repair
title_short The roles and applications of neural stem cells in spinal cord injury repair
title_sort roles and applications of neural stem cells in spinal cord injury repair
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465243/
https://www.ncbi.nlm.nih.gov/pubmed/36105599
http://dx.doi.org/10.3389/fbioe.2022.966866
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