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Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review

The expression of the acute-phase reactants C-reactive protein (CRP), α1-antitrypsin (AAT), and secretory leukocyte protease inhibitor (SLPI), is induced in response to inflammation by pro-inflammatory mediators, including interleukin-1β. It is conceivable that acute-phase proteins exert protective...

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Autores principales: Richter, Katrin, Amati, Anca-Laura, Padberg, Winfried, Grau, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465249/
https://www.ncbi.nlm.nih.gov/pubmed/36105198
http://dx.doi.org/10.3389/fphar.2022.981276
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author Richter, Katrin
Amati, Anca-Laura
Padberg, Winfried
Grau, Veronika
author_facet Richter, Katrin
Amati, Anca-Laura
Padberg, Winfried
Grau, Veronika
author_sort Richter, Katrin
collection PubMed
description The expression of the acute-phase reactants C-reactive protein (CRP), α1-antitrypsin (AAT), and secretory leukocyte protease inhibitor (SLPI), is induced in response to inflammation by pro-inflammatory mediators, including interleukin-1β. It is conceivable that acute-phase proteins exert protective functions, when the integrity of an organism is challenged by pathogens or trauma, which result in uncontrolled release of endogenous damage-associated molecular patterns like Toll-like receptor agonists and ATP. Acute-phase proteins can enhance or down-modulate immunity against infections or protect the host against damage caused by over-shooting effector functions of the immune system. CRP is mainly regarded as a pro-inflammatory opsonizing agent that binds to bacteria and damaged host cells thereby contributing to their inactivation and elimination. AAT and SLPI are well known for their anti-protease activity, which protects the lung extracellular matrix against degradation by proteases that are released by activated neutrophil granulocytes. In addition, there is growing evidence, that CRP, AAT, and SLPI can control the biosynthesis, maturation, and secretion of pro-inflammatory cytokines. The purpose of this narrative mini review is to summarize these anti-inflammatory functions with a focus on the negative control of the ATP-induced, inflammasome-dependent secretion of interleukin-1β by monocytes. CRP-, AAT- and SLPI-mediated control of interleukin-1β release involves the activation of unconventional nicotinic acetylcholine receptors that inhibits the ionotropic function of the ATP receptor P2X7. Apart from other functions, CRP, AAT, and SLPI seem to be central elements of systemic negative feedback loops that protect the host against systemic hyperinflammation, barrier dysfunction, and death by multiple organ damage.
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spelling pubmed-94652492022-09-13 Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review Richter, Katrin Amati, Anca-Laura Padberg, Winfried Grau, Veronika Front Pharmacol Pharmacology The expression of the acute-phase reactants C-reactive protein (CRP), α1-antitrypsin (AAT), and secretory leukocyte protease inhibitor (SLPI), is induced in response to inflammation by pro-inflammatory mediators, including interleukin-1β. It is conceivable that acute-phase proteins exert protective functions, when the integrity of an organism is challenged by pathogens or trauma, which result in uncontrolled release of endogenous damage-associated molecular patterns like Toll-like receptor agonists and ATP. Acute-phase proteins can enhance or down-modulate immunity against infections or protect the host against damage caused by over-shooting effector functions of the immune system. CRP is mainly regarded as a pro-inflammatory opsonizing agent that binds to bacteria and damaged host cells thereby contributing to their inactivation and elimination. AAT and SLPI are well known for their anti-protease activity, which protects the lung extracellular matrix against degradation by proteases that are released by activated neutrophil granulocytes. In addition, there is growing evidence, that CRP, AAT, and SLPI can control the biosynthesis, maturation, and secretion of pro-inflammatory cytokines. The purpose of this narrative mini review is to summarize these anti-inflammatory functions with a focus on the negative control of the ATP-induced, inflammasome-dependent secretion of interleukin-1β by monocytes. CRP-, AAT- and SLPI-mediated control of interleukin-1β release involves the activation of unconventional nicotinic acetylcholine receptors that inhibits the ionotropic function of the ATP receptor P2X7. Apart from other functions, CRP, AAT, and SLPI seem to be central elements of systemic negative feedback loops that protect the host against systemic hyperinflammation, barrier dysfunction, and death by multiple organ damage. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465249/ /pubmed/36105198 http://dx.doi.org/10.3389/fphar.2022.981276 Text en Copyright © 2022 Richter, Amati, Padberg and Grau. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Richter, Katrin
Amati, Anca-Laura
Padberg, Winfried
Grau, Veronika
Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title_full Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title_fullStr Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title_full_unstemmed Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title_short Negative regulation of ATP-induced inflammasome activation and cytokine secretion by acute-phase proteins: A mini review
title_sort negative regulation of atp-induced inflammasome activation and cytokine secretion by acute-phase proteins: a mini review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465249/
https://www.ncbi.nlm.nih.gov/pubmed/36105198
http://dx.doi.org/10.3389/fphar.2022.981276
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